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- 2Field, Catherine J.
- 1Bhardwaj, Paramjit P
- 1Bhardwaj, Paramjit Paul
- 1Burgess, Denee
- 1Dobberthien, Brennen Jay
- 1Ghoshal, Bibaswan
Numerous investigations have suggested that dysregulation of the neurotransmitter glutamate (Glu) plays an important role in certain neuropsychiatric disorders, like depression. Pregnancy and the postpartum period are associated with the most substantial physiological alteration of female...
Sourdough fermentation can generate various peptides and amino acids to improve bread quality, such as taste, flavor and texture. The aim of this PhD dissertation was to investigate the synthesis mechanisms of bioactive and taste active peptides or amino acids during fermentation and their effect...
In rodents, stress and corticosteroids rapidly increase excitatory neurotransmission. During excitatory neurotransmission, glutamate concentrations are maintained by conversion of glutamine to glutamate. The hypothesis was that cortisol would alter human prefrontal glutamine or glutamate...
Glutamate Levels in the Medial Prefrontal Cortex of Healthy Women during Pregnancy and the PostpartumDownload
The substantial female hormone fluctuations associated with pregnancy and the postpartum have been linked to a greater risk of developing depressive symptoms. Glutamate (Glu) has been implicated in the pathophysiology of major depression. The objective of this thesis was to investigate MPFC Glu...
Risk factors for postpartum depression (PPD) include history of a major depressive episode, premenstrual dysphoric disorder, or a prior episode of PPD. Fluctuations in estrogen, progesterone, and neuroactive steroids occur in the postpartum, and these molecules act as modulators of a number of...
New role of glutamate as an immunoregulator via glutamate receptors and transporters.
Membrane transporters play integral roles in the functioning of cells by controlling movement of molecules across the phospholipid bilayer. In this thesis, utilization of radioisotope uptake assays permitted examination of intentional and unintentional inhibition of three membrane transporter...
Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 proteinDownload
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
Spectral Editing for Detection of Oncologically Relevant Metabolites with In-Vivo Magnetic Resonance Spectroscopy at 9.4 TDownload
Short echo time (TE) magnetic resonance spectroscopy (MRS) techniques with spectral fitting are commonly employed approaches for brain metabolite quantification at 9.4 T. However, there is a significant overlap of peaks in short-TE spectra, even at 9.4 T. To better resolve resonances, spectral...
The intestine and the gut-associated lymphoid tissue (GALT) are essential components of whole body immune defense, protecting the body from foreign antigens and pathogens, while allowing tolerance to commensal bacteria and dietary antigens. The requirement for protein to support the immune system...