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Glaucoma is a neurodegenerative disease which is among the leading causes of blindness in the world. Glaucoma is characterized by progressive visual field loss, caused by retinal ganglion cell (RGC) death. Both surgical glaucoma treatments and medications are available; however, they only halt...
Distinct Roles of Class 1 PI3K Isoforms in the Regulation of Beta Cell Exocytosis and Insulin SecretionDownload
Type 2 diabetes (T2D) is characterized by peripheral insulin resistance and an insufficiency of insulin secretion from the pancreatic beta cell. The incidence of T2D is rising worldwide at an alarming rate. An increase in population growth, increased prevalence of obesity, and an aging population...
Glomus cells of the carotid body are peripheral chemoreceptors that detect changes in arterial oxygen levels. Hypoxia suppresses oxygen-sensitive K+ channels in glomus cells, resulting in cytosolic [Ca2+] ([Ca2+]i) elevation in glomus cells via the activation of voltage-gated Ca2+ channels. The...
Mast cells are tissue-resident immune cells that undergo exocytosis upon activation, releasing potent immunoregulatory molecules that initiate inflammatory responses. Here, I investigated the role of the hematopoietic specific Rho GTPase, Rac2, and the ubiquitous, Rac1, on mast cell exocytosis....