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- 5Endothelial cells
- 1Chloride intracellular channel
- 1Farhan, Maikel AA
- 1Haddad, George
- 1Jurasz, P.
- 1Moncada de la Rosa, C.
- 1Nakhaei-Nejad, Maryam
- 1Radziwon-Balicka, A.
Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of actionDownload
Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
Renal glomeruli are specialized capillaries that produce a protein-free ultrafiltrate of plasma at an extremely high rate. Glomerular endothelial cells (EC) and podocytes sustain the integrity of filtration barrier, and glomerular mesangial cells provide intravascular support. Podocytes cover...
Thrombotic microangiopathies are group of diseases that refer to clinical and pathological syndromes where endothelial injury results in the manifestations of capillary thrombosis, microangiopathic hemolytic anemia, schistocytosis, and can lead to renal failure. In this thesis we aimed to study...
Leukocyte extravasation is a fundamental process of the inflammatory responses. The mechanisms that control remodelling of endothelial (EC) shape and adhesive contacts during leukocyte transendothelial migration (TEM) are not completely understood. We studied the role of EC phosphatidylinositol...