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Skip to Search Results- 1Canham, Lindsay C
- 1Cox, Pendleton J M
- 1Dey, Dipanjan
- 1Galenza, Anthony
- 1Heslip, Tim.
- 1MacKay, Julie Olivia.
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Spring 2015
Besides being the most popular drug in the world, caffeine is an attractive tool used in research to help us answer fascinating scientific questions, because caffeine impinges on a number of molecular pathways. In my research, I used caffeine to study DNA repair pathways and insect xenobiotic...
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Fall 2015
In differentiating cells, genes are silenced or transcribed through changes in chromatin organization. Active chromatin is known as euchromatin and repressive chromatin is known as heterochromatin. These active or repressive states are initiated and maintained by modifying residues of the core...
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Characterizing novel genes involved in steroidogenesis during the larval development in Drosophila melanogaster
DownloadSpring 2022
The primary steroid hormone in Drosophila melanogaster is called ecdysone, which is synthesized in the larval prothoracic gland (PG) during developmental processes. Ecdysone biosynthesis is significantly up-regulated at the beginning of the third larval instar, resulting in a major ecdysone pulse...
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DHR51 as a coordinator of heme biosynthesis and steroid hormone production to time metamorphosis in Drosophila melanogaster
DownloadFall 2019
Development from a juvenile to an adult animal is driven by pulses of steroid hormones released at precise developmental times. Inputs from the environment, timing cues, and nutritional factors are all coordinated to produce a steroid hormone pulse. Insects and in particular, the fruit fly...
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Spring 2017
Pulses of ecdysone, a steroid hormone, play an integral role during insect development however, how these ecdysone pulses are regulated has been relatively unexplored. I have shown that the presence of nitric oxide (NO) within the larval prothoracic gland (PG), the principal source of larval...
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Fall 2020
Ecdysone, the primary steroid hormone in insects produced primarily in the prothoracic gland during larval development, is responsible for coordinating developmental transitions such as larval molts and metamorphosis during the Drosophila life-cycle. The ecdysone biosynthesis pathway, which...
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Genetic, genomic and molecular studies of signaling pathways controlling ecdysone biosynthesis in Drosophila melanogaster
DownloadFall 2013
In insects, periodic pulses of the molting hormone ecdysone control all major developmental transitions such as the molts and metamorphosis. Ecdysone, a steroid hormone, is produced in the prothoracic gland during larval and pupal development of Drosophila. While we have a relatively good...
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Fall 2020
Interactions between diet, lifespan, metabolism, and immunity are complex but can have profound impact on human health. The Drosophila model is useful to study these interactions as many pathways and processes are highly conserved between flies and humans. In this thesis, I used the defined...