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Skip to Search Results- 1Bohn, Linzy M
- 1Cochrane, Karen
- 1Davis, Christopher MJ
- 1Ding, Julia-lin
- 1Earle, Kelsey F.
- 1Fleck, Shelaine
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Fall 2014
The present research examined social motivation in dementia within the theoretical framework of socioemotional selectivity theory (SST; Carstensen, 2006). SST is a lifespan theory of social motivation that argues goal selection and pursuit are inextricably related to perceived time remaining in...
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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Dementia Care: Effects of Care Load and Couple Age on Perceptions of Abuse, Abuser, and Abused
DownloadSpring 2020
Abuse is the intentional act, or failure to act, by a person that creates harm or risk of harm to another individual (Center for Disease Control and Prevention, 2019a). This issue is particularly relevant in healthcare scenarios because of older adults' increased vulnerability. The prevalence of...
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Fall 2021
Chronological aging is one of the greatest risk factors of tauopathies, yet our understanding about the underlying molecular mechanism is limited. Studying physiological aging often requires an extended timeline and thus presents a significant hurdle for modeling late-onset disorders. In this...
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Exploration of Institutional Dementia Care: Social Engagement and the Use of Physical Restraints
DownloadFall 2012
Social engagement has been established as an important indicator of quality of life. For individuals with dementia, entering an institution can accelerate their exclusion from the social world of their healthy peers (Kitwood, 1997). This study examined social engagement and physical restraint use...