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Ocular gene transfer communications: Developing ethical frameworks for phase I choroideremia clinical trials
Download2013-06
I investigate how to ethically communicate about a phase I gene transfer trial for choroideremia, a blinding retinopathy, in light of this novel biotechnology’s portrayal as a potential ‘cure’. I analyzed gene transfer communications in three contexts: (1) interviews with clinicians (n=15),...
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2017-11
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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2014-11
Choroideremia (CHM) is an inherited X-linked retinal dystrophy that causes hemizygous males to develop nyctalopia and a progressive loss of their peripheral visual field until only central vision remains. At the end stages of the degeneration, central acuity is also affected. The onset and rate...