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- 6Chemical isotope labeling
- 1Biomarker discovery
- 1Blood metabolomics
- 1Data processing
Metabolomics is the ultimate reflection of organisms influenced by both genetic and environmental factors. Compared with other omics areas, it is the most appropriate and closest description of phenotype, which is the comprehensive characteristics of an organism. It is a powerful tool for global...
Development and Application of Chemical Isotope Labeling Methods and Metabolite Identification Solution for Liquid Chromatography-Mass Spectrometry-Based MetabolomicsDownload
Metabolomics, the comprehensive analysis of small molecules in biological specimens, has become an emerging and indispensable tool for systems biology and clinical research. Liquid chromatography-mass spectrometry (LC-MS) is a dominant analytical platform for metabolomics, featuring high...
Development and Application of Chemical Isotope Labeling Methods for Metabolomics Data Processing and Liquid Chromatography-Mass Spectrometry-Based MetabolomicsDownload
Metabolomics is the study of chemical processes involving small-molecule metabolites in a given biological system. These small molecules are downstream outputs of cellular activities. An understanding of the metabolome change can help us to visualize perturbations in the genome or proteome from...
Development of Blood Metabolomics for Biomarker Discovery Using Chemical Isotope Labeling and Liquid Chromatography-Mass SpectrometryDownload
Blood-metabolite-based biomarkers are useful for the early-stage diagnosis, accurate prognostic prediction and personalized treatment of various diseases. Blood contains a massive number of metabolites that can potentially become biomarkers, but the metabolome coverage of current analytical...
Development of Data Processing Methods in Chemical Isotope Labeling Liquid Chromatography-Mass Spectrometry-Based MetabolomicsDownload
Metabolomics is an active research field on the methods development for the analysis of small metabolites in biological systems. It provides powerful approaches that allow us to examine the variations in the metabolic profiles and is capable of detecting complex biological changes using...
The most often used biofluids in metabolomics and disease biomarker discovery studies in the literature include urine, processed blood (serum or plasma), and cerebral spinal fluid. While investigations using these biofluids have led to numerous innovations in the field of metabolomics, little...