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- 2Placental Insufficiency
- 1Animal Model
- 1BUAL
- 1Bilateral uterine artery ligation
- 1Brain damage
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Alterations in Neural Connectivity following Placental Insufficiency, its Role in Neurodevelopmental Disabilities, and the Neuropreventive Effects of Broccoli Sprout Supplementation: A Potential Therapeutic Intervention
DownloadFall 2017
Background Intrauterine growth restriction (IUGR) as a result of suboptimal in utero environments can cause perinatal brain injury and ultimately lead to neurodevelopmental disorders (NDD). In the developed world placental insufficiency (PI) is the leading cause of IUGR. This antepartum insult...
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Bilateral Uterine Artery Ligation in Rats cultivates Long Term Neurological Deficits reminiscent of Human Cerebral Palsy: A model for Therapeutic Intervention.
DownloadFall 2015
Introduction Cerebral Palsy (CP) is a ubiquitous term used to describe a group of permanent, non-progressive disorders of movement, posture, and behaviour. Despite countless advances in neonatal medicine, the incidence of CP has remained constant in term infants over the last three decades. More...
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Hypothermia and the Evaluation of Combination Therapies for Neonatal Hypoxic-Ischemic Brain Damage
DownloadFall 2016
Hypoxic-ischemic brain damage (HIBD) is still of major concern in the neonatal period, resulting in chronic neurological sequelae stemming from damage to the term newborn brain. Full-body and focal-head cooling within 6 hours of birth have proven neuroprotective in human newborns and various...
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Investigating the Role of In Utero Inflammation on Neurodevelopment in the Fetus and Offspring and the Neuroprotective Properties Afforded by Broccoli Sprouts
DownloadFall 2016
Introduction Maternal infection and inflammation leading to a fetal inflammatory response (FIR) is a risk factor for perinatal brain damage. Perinatal brain injury can lead to neurodevelopmental disorders, the sine quo non outcome parameter of which is cerebral palsy (CP). Despite advances in...
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Spring 2016
Cerebral Palsy (CP) constitutes the primary outcome of premature nerve injury. Impairment of oxygen and glucose supply during pregnancy to the fetus can induce neuron damage and death. Mental retardation, seizures, learning disabilities, and other mental diseases can occur as a result of this...