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- 3Cancer therapy
- 1COX-2 inhibitor
- 1Cyclooxygenase-2 inhibitor
- 1Protein silencing
Characterization of the response of melanoma cell lines to inhibition of anti-apoptotic Bcl-2 proteinsDownload
Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma’s striking resistance to apoptosis. ABT-737, a small-molecule inhibitor of...
Cancer remains to be one of the deadliest diseases world-wide due to its effect on millions of lives per year. The discovery of RNA interference and delivery of siRNA (small-interfering RNA) for protein silencing have been widely used for treatment of cancer cells. Research in our lab focuses on...
Evaluation of selective cyclooxygenase-2 (COX-2) inhibitors as radiosensitizing agents for cancer therapyDownload
Tumour resistance to chemo- and radiotherapy often prevents successful cancer therapy. This has promoted the search for novel agents that target specific molecular pathways linked to tumour resistance to cancer therapy. Among these novel agents are inhibitors of the inducible isoform of the...