This weekend, we need to do work to address a component of our application that requires immediate attention. As a result, you may experience ERA to be intermittently available. We apologize for any inconvenience this may cause, and thank you for your patience as we attend to the care and feeding of ERA!
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Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
Study of calcineurin interaction with inhibitor-1 and natural products. Towards novel calcineurin inhibitorsDownload
Calcineurin (CaN) is an eukaryotic Ser/Thr protein phosphatase that plays an important role in lymphocyte activation. Inhibition of CaN leads to immune system suppression, a necessary procedure in organ transplantation. However, use of CaN inhibitors results in toxic side effects. The search for...