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Fall 2020
Background: The CRISPR/Cas9 system has emerged as a revolutionary genetic engineering technology capable of editing various cell types, creating disease models, and more recently, changing human DNA1 . It consists of three pieces: the Cas9 endonuclease, the gRNA, and the DNA target. In short, the...
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Fall 2021
Neurodegenerative diseases caused by prions afflict both humans and animals, and result from conformational conversion of the cellular prion protein, PrPC, coded for by the PRNP gene, to an isoform called PrPSc. The infectious agent of PrPSc assembles into aggregate structures and can continue...