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Optimization, adaptation and application of protein misfolding cyclic amplification to detection of prions in blood plasma
DownloadFall 2010
The PMCA assay was optimized for adaptation to low level detection of PrPSc in hamster plasma. Evaluation of numerous key variables of the PMCA assay led to an optimized protocol capable of ~3 log10 amplification after 32 cycles (two 16 hour rounds). When commercially purchased normal hamster...
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Spring 2011
Transfusion medicine is dependent upon the ability to hypothermically preserve red blood cell (RBC) function ex vivo. Recent evidence suggests that the deformability of hypothermically stored RBCs may be compromised, potentially leading to microvasculature occlusion and tissue hypoxia in...