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- 1CTP:phosphocholine cytidylyltransferase
- 1Docosahexaenoic acid
- 1Epoxydocosapentaenoic acids
Docosahexaenoic acid (22:6n3, DHA) is an n-3 polyunsaturated fatty acid (PUFA) that is known to induce context-dependent cell survival, as well as apoptosis, but the exact cellular and molecular mechanism(s) remain unknown. DHA is known to act as a natural ligand for the peroxisome...
Insights into the role of CTP:phosphocholine cytidylyltransferase-alpha in hepatic lipid metabolism and cellular integrityDownload
Lower levels of hepatic phosphatidylcholine (PC) are suggested to play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). Mice lacking hepatic CTP:phosphocholine cytidylyltransferase-α (LCTα-/-), the regulatory enzyme in the CDP-choline pathway for PC biosynthesis, were fed a...