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- 1Abdualla, Radya Y
- 1Caballero, Hebert S
- 1Chaudhary, Ketul R
- 1Freitag, Ian J
- 1Gragasin, Ferrante S.
- 1Hu, Xiaobin
Von Willebrand Factor (VWF) is a multimeric adhesive glycoprotein that is exclusively expressed in endothelial cells (EC) and megakaryocytes. This procoagulant protein is involved in maintaining primary hemostasis and thrombus formation. However, there are pathological and physiological...
An increasing life expectancy in Canada has resulted in increasing proportions of elderly patients requiring anesthetic care for surgical procedures. Aging is associated with cardiovascular changes resulting in increased vasoconstriction and hypertension, and medications such as angiotensin...
Objective: Clinical utility of the Mild Cognitive Impairment (MCI) classification is diminished by uncertainty regarding procedures for detecting preceding transitions from normal aging (NA) and future transitions to Alzheimer’s disease (AD). AD genetic markers may clarify underlying...
Exploring barriers and facilitators to the implementation of healthy aging policy in suburban planning and transportation departmentsDownload
Purpose: The purpose of this research was examine potential barriers and facilitators to the implementation of healthy public policy related to aging, specifically in municipal planning and transportation departments, in the suburban context. Research Questions: What are the factors which...
Mitochondrial dysfunction is considered as a key mechanism of aging but little is known about the impact of mitochondrial biogenesis. Mitochondrial DNA (mtDNA) copy number control is an important aspect of mitochondrial biogenesis and is highly regulated in eukaryotic organisms. By studying mtDNA...
Integrating Characteristics of Executive Functions in Non-Demented Aging: Structure, Trajectories, Classification, and Biomarker PredictorsDownload
In aging, executive function (EF) performance (level) and change (trajectory) are linked to multiple interacting risk factors. Structurally, EFs have previously been represented as either a unitary (e.g., unidimensional) or diverse (e.g., multidimensional) set of abilities that change across the...
Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...
Background. Context use in sentence comprehension is fairly resistant to age-related cognitive decline; however, event-related potentials (ERPs) studies have shown age effects in neural activity associated with sentence comprehension, specifically when contextual information is manipulated. One...
Older Adults and Generativity: Developmental, Experimental, and Clinical Advances in Terror Management TheoryDownload
Terror Management Theory (TMT) (Greenberg, Pyszczynski, & Solomon, 1986) offers an empirical framework to explore how human beings function despite their fear of death. TMT studies have shown that in order to buffer death anxiety, people strive to meet the standards of their cultural worldview. ...
Narratives of King Solomon’s life and reign are preserved in both the Book of Kings and the Book of Chronicles, and both texts contain similar narrative elements and mnemonic constructions, such as Solomon’s role as Temple builder and his great wisdom. Other elements of the narrative have been...