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- 3Fliegel, Larry
- 2Wang, Huayan
- 1Amyotte, Josee J.
- 1Arlian, Britni M.
- 1Bekele, Raie T.
- 1Benesch, Matthew
- 3Biochemistry, Department of
- 3Biochemistry, Department of/Journal Articles (Biochemistry)
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Chemistry, Department of
- 2Chemistry, Department of/Journal Articles (Chemistry)
Activation of Delayed and Fluid Petroleum Coke for the Adsorption and Removal of Naphthenic Acids from Oil Sands Tailings Pond WaterDownload
Oil sands companies produce substantial quantities of tailings known to contain high concentrations of dissolved organic by-products. The use of petroleum coke was proposed as a potential adsorbent for organic contaminant removal from tailings pond water. Physical activation was used to create a...
Defects in DNA replication and chromosome condensation are common phenotypes in cancer cells. A link between replication and condensation has been established, but little is known about the role of checkpoints in monitoring chromosome condensation. We investigate this function by live analysis,...
Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22
Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22...
Goldfish ghrelin: Molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intakeDownload
Complementary deoxyribonucleic acid (cDNA) encoding goldfish preproghrelin was identified using rapid amplification of the cDNA ends (RACE) and reverse transcription (RT)-polymerase chain reaction (PCR). The 490 bp cDNA encodes a 103 amino acid preproghrelin which has a 26 amino acid signal...
Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistanceDownload
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
Regulation of Na+/H+ Exchanger Gene Expression: Role of a poly T rich region in regulation of expression of the NHE1 promoterDownload
In this study we examine regulation of expression of the Na+/H+ exchanger promoter in L6 and NIH 3T3 cells. We have identified a highly conserved poly(dA·dT)-rich region that appears to be important in regulation of expression of the NHE1 gene. Deletion or mutation of this region results in...
Sialic acid terminates glycans of glycoproteins and glycolipids that play numerous biological roles in health and disease. Although genetic tools are available for interrogating the effects of decreased or abolished sialoside expression in mice, pharmacological inhibition of the sialyltransferase...
The Na+/H+ exchanger potentiates growth and retinoic acid induced differentiation of embryonal carcinoma cellsDownload
The Na+/H+exchanger is a ubiquitous plasma membrane protein that is responsible for pH regulation and is activated by growth factors. We examined the role of the Na+/H+ exchanger in cell growth and differentiation. Treatment of P19 cells with the Na+/H+ exchanger inhibitor Hoe 694 eliminated...
The effect of a go/no-go naming task on fMRI BOLD activation in the ventral visual processing streamDownload
Background: The go/no-go naming behavioural paradigm has furthered our understanding of basic reading processes, however, its neural representations remain largely unknown. Pilot data using this task (with nonwords) produced fMRI ventral stream activation for regular and exception words. This...