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Skip to Search Results- 2Macauley, Matthew S.
- 1Bubb, Abigail K.
- 1Davies, Gideon J.
- 1Martinez-Fleites, Carlos
- 1Natoni, Alessandro
- 1O’Dwyer, Michael E.
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Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance
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Bubb, Abigail K., Macauley, Matthew S., Davies, Gideon J., Vocadlo, David J. , Martinez-Fleites, Carlos
The O-GlcNAc post-translational modification is considered to act as a sensor of nutrient flux through the hexosamine biosynthetic pathway. A cornerstone of this hypothesis is that global elevation of protein O-GlcNAc levels, typically induced with the non-selective O-GlcNAcase inhibitor PUGNAc...
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2016
O’Dwyer, Michael E., Macauley, Matthew S., Natoni, Alessandro
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and...