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Freshwater Sponges Have Functional, Sealing Epithelia with High Transepithelial Resistance and Negative Transepithelial Potential
Download2010
Leys, S.P., Goss, G.G., Adams, E.D.M.
Epithelial tissue — the sealed and polarized layer of cells that regulates transport of ions and solutes between the environment and the internal milieu — is a defining characteristic of the Eumetazoa. Sponges, the most ancient metazoan phylum [1], [2], are generally believed to lack true...
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Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells
Download1998
Vandorpe, D.H., Izumo, S., Malek, A.M., Goss, G.G., Jiang, L., Alper, S.L.
Background and Purpose—Hyperosmotic mannitol therapy is widely used in the clinical setting for acute and subacute reduction in brain edema, to decrease muscle damage in compartment syndrome, and to improve renal perfusion. Though beneficial rheological effects commonly are attributed to...
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Na+/H+ exchange activity during phagocytosis in human neutrophils: Role of Fc7 receptors and tyrosine kinases
Download1996
Downey, G. P., Orlowski, J., Goss, G.G., Grinstein, S., Waddell, T. K., Fukushima, T.
Abstract. In neutrophils, binding and phagocytosis facilitate subsequent intracellular killing of microorganisms. Activity of Na+/H ÷ exchangers (NHEs) participates in these events, especially in regulation of intracellular pH (pHi) by compensating for the H ÷ load generated by the respiratory...
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2010
Sensen, C.W., Goss, G.G., Childs, S.J., Zuccolo, J., Bau, J., Deans, J.P.
Background: The MS4A gene family in humans includes CD20 (MS4A1), FcRb (MS4A2), Htm4 (MS4A3), and at least 13 other syntenic genes encoding membrane proteins, most having characteristic tetraspanning topology. Expression of MS4A genes is variable in tissues throughout the body; however, several...