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Spring 2018

Akgun, Burcin

The development of rapid and bioorthogonal chemical reactions has expanded greatly the utility of bioconjugation chemistry in the service of site-selective protein labeling, even allowing molecular imaging in live cells or animals. ‘Click’ chemistry is particularly desirable due to its fast...

Fall 2015

Fatemi, Solmaz

Direct condensation between a carboxylic acid and amine must overcome the initial formation of a thermodynamically stable and unreactive carboxylate-ammonium salt, providing the amide product only at very high temperatures (over 160 oC) that are incompatible with many functionalized molecules....