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Investigating the Role of PCSK9 C-terminal Domain in the Regulation of Low-Density Lipoprotein Receptor and Cholesterol Metabolism
DownloadSpring 2020
Atherosclerotic cardiovascular disease (CVD) is the leading cause of death worldwide. Long-term elevated low-density lipoprotein cholesterol (LDL-C) levels are the major risk factors for the development of atherosclerotic lesions, which can eventually lead to myocardial infarction and many...
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Fall 2013
ATP-binding cassette transporter G1 (ABCG1) mediates sterol efflux onto lipidated lipoproteins and plays an important role in macrophage cholesterol homeostasis. In this project, we investigated how ABCG1 works as a functional transporter to mediate sterol translocation. First, we found a...
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Spring 2023
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality worldwide. Long-term elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) are the major risk factors for developing atherosclerotic lesions, which can eventually lead to myocardial...