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- 2Sigalet, David L.
- 1Aboelnazar, Nader Saber
- 1Abualhassan, Nasser
- 1Aggarwal, Saloni
- 1Ahmed, Mohammed
- 1Akhrorov, Murodbek
- 7Mesenchymal stem cells
- 6Islet transplantation
- 5Cerebrovascular spasm--Animal models
Video is widely used in modern surgical education and may have advantages over other ways of learning surgery. However, less is known about the purposes and needs of surgical learners who use videos, as well as what learners consider to be the attributes of a ‘good’ surgical video. Qualitative...
Cardiovascular dysfunction in asphyxiated neonates leads to significant morbidity and mortality and the hemodynamic support is limited to the use of catecholamines. In a pilot study, we showed that low-dose vasopressin improved myocardial tissue lactate levels, suggesting decreased anaerobic...
Utilizing Positron Emission Tomography to Detect Functional Changes Following Drug Therapy in a Renal Cell Carcinoma Mouse ModelDownload
Sunitinib is currently the first line drug therapy for metastasizing renal cell carcinoma (RCC). It has been shown to have a profound effect on tumor angiogenesis leading to modifications of the tumor’s microenvironment. Tumor hypoxia plays an important role in the metastatic potential of a solid...
Trophic peptide therapies for neonatal short bowel syndrome: actions and mechanisms studied in a preclinical modelDownload
Short bowel syndrome (SBS) occurs when a significant length of intestine is surgically resected for both congenital and acquired intestinal abnormalities and remains a significant cause of morbidity and mortality in neonates. With an insufficient amount of intestine available for nutrient...
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...
Lung cancer has the highest mortality rates of all cancers worldwide, with a 5-year survival rate less than 15%. Screening methods are in need for the high risk population, as lung cancer is asymptomatic in its early stages. Proper screening methods would allow earlier diagnosis and curative...
Tolerance to neonatal porcine islet xenografts induced by a combination of monoclonal antibodiesDownload
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...