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- 2Sigalet, David L.
- 1Aboelnazar, Nader Saber
- 1Abualhassan, Nasser
- 1Aggarwal, Saloni
- 1Ahmed, Mohammed
- 1Akhrorov, Murodbek
- 7Mesenchymal stem cells
- 6Islet transplantation
- 5Cerebrovascular spasm--Animal models
Utilizing Positron Emission Tomography to Detect Functional Changes Following Drug Therapy in a Renal Cell Carcinoma Mouse ModelDownload
Sunitinib is currently the first line drug therapy for metastasizing renal cell carcinoma (RCC). It has been shown to have a profound effect on tumor angiogenesis leading to modifications of the tumor’s microenvironment. Tumor hypoxia plays an important role in the metastatic potential of a solid...
Development of the axial skeleton in vertebrates begins with the segmentation of the paraxial mesoderm into somites. Somites are transient structures in the embryos that ultimately give rise to the skeletal muscle, dermis, tendons, cartilage, and bony structures of the axial skeleton. Once...
With asphyxia, newborns may suffer cardiogenic shock with myocardial dysfunction and dysregulation of vasomotor tone resulting in multiorgan dysfunction. Vasoactive medications are often administered with limited evidence directing clinicians regarding the use of high-dose monotherapy with...
The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells occurs in both natural and artificially induced states of lymphopenia. Although lymphopenia leads to homeostatic proliferation of T...
The use of experimental animals early in the twentieth century has revolutionized medicine and significantly improved our understanding of disease processes. The ability to reproduce a medical condition in a mouse model has provided great insights into the cellular and molecular biology of the...
Peripheral nerve regeneration: A study of surgical and biological techniques to enhance functional regenerationDownload
Unlike the central nervous system, axonal regeneration does occur in the peripheral nervous system, however, despite this, functional recovery from nerve transection injury remains dismal. This has been attributed to factors intrinsic to the motor or sensory cell body and to elements in the...
Islet transplantation is promising treatment for certain patients with type 1 diabetes who experience recurrent episodes of hypoglycemia with unawareness. One opportunity to improve on islet transplant outcomes and potentially broaden the recipient population, is to reduce the early post...
Access to ABO-incompatible (ABOi) organ transplantation has expanded donor availability for patients with end-stage organ failure. Determination of eligibility for safe ABOi transplantation and effective post-transplant management to deal with potential ongoing antibody production are dependent...