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1990

Chetner, Michael Phineas.

Spring 2013

Chapman, David W

Sunitinib is currently the first line drug therapy for metastasizing renal cell carcinoma (RCC). It has been shown to have a profound effect on tumor angiogenesis leading to modifications of the tumor’s microenvironment. Tumor hypoxia plays an important role in the metastatic potential of a solid...

Spring 2018

Lavy, Rotem

Development of the axial skeleton in vertebrates begins with the segmentation of the paraxial mesoderm into somites. Somites are transient structures in the embryos that ultimately give rise to the skeletal muscle, dermis, tendons, cartilage, and bony structures of the axial skeleton. Once...

Fall 2010

Manouchehri, Namdar

With asphyxia, newborns may suffer cardiogenic shock with myocardial dysfunction and dysregulation of vasomotor tone resulting in multiorgan dysfunction. Vasoactive medications are often administered with limited evidence directing clinicians regarding the use of high-dose monotherapy with...

Fall 2011

Thangavelu, Govindarajan

The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells occurs in both natural and artificially induced states of lymphopenia. Although lymphopenia leads to homeostatic proliferation of T...

Fall 2016

Abualhassan, Nasser

The use of experimental animals early in the twentieth century has revolutionized medicine and significantly improved our understanding of disease processes. The ability to reproduce a medical condition in a mouse model has provided great insights into the cellular and molecular biology of the...

Fall 2009

Ladak, Adil

Unlike the central nervous system, axonal regeneration does occur in the peripheral nervous system, however, despite this, functional recovery from nerve transection injury remains dismal. This has been attributed to factors intrinsic to the motor or sensory cell body and to elements in the...

1993

Graham, A. J.

Fall 2011

McCall, Michael David

Islet transplantation is promising treatment for certain patients with type 1 diabetes who experience recurrent episodes of hypoglycemia with unawareness. One opportunity to improve on islet transplant outcomes and potentially broaden the recipient population, is to reduce the early post...

Fall 2014

Jeyakanthan, Mylvaganam

Access to ABO-incompatible (ABOi) organ transplantation has expanded donor availability for patients with end-stage organ failure. Determination of eligibility for safe ABOi transplantation and effective post-transplant management to deal with potential ongoing antibody production are dependent...