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- 2Hegadoren, Kathleen M.
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
- 1Armstrong, Jeff
Gambling is a recreational activity enjoyed by many; however, for some this enjoyment can lead to the development of Gambling Disorder with financial, personal, and psychological ramifications. The study of pathological gamblers has targeted the psychological, behavioural and neurobiological...
Cannabis use is a known risk factor for the development of psychotic disorders. Clinical and preclinical genetic studies provide growing evidence that genes related to dopamine signalling and neuroprotection, like COMT, are implicated in the cannabis-psychosis association. Considering the burden...
Depression is a common, recurrent and frequently chronic mental health disorder that has already become one of the leading health-care burdens. Despite the wide clinical application of antidepressants, a significant portion of patients does not benefit sufficiently from the standard medication...
The Antidepressant/Antipanic/Neuroprotective Drug Phenelzine: Neuropharmacological and Drug Metabolism StudiesDownload
Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic and neuroprotective properties. Metabolites of PLZ were investigated in rat brain. Levels of phenylacetic acid (PAA) and β-phenylethylamine (PEA) were found to be elevated after administration of PLZ and PEH...
Glutamate Levels in the Medial Prefrontal Cortex of Healthy Women during Pregnancy and the PostpartumDownload
The substantial female hormone fluctuations associated with pregnancy and the postpartum have been linked to a greater risk of developing depressive symptoms. Glutamate (Glu) has been implicated in the pathophysiology of major depression. The objective of this thesis was to investigate MPFC Glu...
Major depression (MD) is one of the most prominent medical conditions worldwide in terms of societal cost and morbidity. MD has been associated with increased risk for cardiovascular disease (CVD) and conversely CVD has been associated with increased MD symptoms. Previous studies have shown that...
This thesis contributes to the growing body of gender-specific health research by integrating both psychological and neuroendocrine data to assess the impacts of stress and violence on women's health. Women seeking support for intimate partner violence (IPV) were compared with women seeking...
Prescription of high dose antipsychotics remains a common practice, contrary to available evidence. Studies have found that, on average, high daily doses of antipsychotics are no more effective or are less effective than are moderate doses, and have indicated that higher doses are associated with...
Individuals with human immunodeficiency virus (HIV) develop neurocognitive impairments, more frequently as the systemic disease progresses to AIDS. Among HIV-infected persons receiving antiretroviral therapy, executive dysfunctions are very commonly impaired. The present study examined...