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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Adu, Medard Kofi
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
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Fall 2010
Insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a single trans-membrane glycoprotein that is widely but selectively distributed throughout the central nervous system (CNS). IGF-II/M6P receptor is involved in the trafficking of M6P-containing lysosomal enzymes from the...
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Phasic Electrodermal Activity in Schizophrenia: Skin Conductance Response in Unmedicated Schizophrenic Patients in Comparison to Normal Controls
DownloadSpring 2012
Stimulus-elicited (phasic) skin conductance responses (SCRs) to indifferent stimuli have often been employed to examine abnormalities in orienting (allocation of attention) in studies of schizophrenia. Most previous studies have examined phasic activity only during habituation paradigms....
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Fall 2011
Risk factors for postpartum depression (PPD) include history of a major depressive episode, premenstrual dysphoric disorder, or a prior episode of PPD. Fluctuations in estrogen, progesterone, and neuroactive steroids occur in the postpartum, and these molecules act as modulators of a number of...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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The Antidepressant/Antipanic/Neuroprotective Drug Phenelzine: Neuropharmacological and Drug Metabolism Studies
DownloadSpring 2013
Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic and neuroprotective properties. Metabolites of PLZ were investigated in rat brain. Levels of phenylacetic acid (PAA) and β-phenylethylamine (PEA) were found to be elevated after administration of PLZ and PEH...
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Glutamate Levels in the Medial Prefrontal Cortex of Healthy Women during Pregnancy and the Postpartum
DownloadFall 2012
The substantial female hormone fluctuations associated with pregnancy and the postpartum have been linked to a greater risk of developing depressive symptoms. Glutamate (Glu) has been implicated in the pathophysiology of major depression. The objective of this thesis was to investigate MPFC Glu...
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Spring 2021
Alcohol use disorder (AUD) is one of the most prevalent, harmful, and costly preventable disorders in the world. AUD is associated with wide-spread structural and functional brain deficits, which are at least partially reversible with sustained abstinence. The most rapid recovery is thought to...
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Pharmacogenomics for Psychiatry: Focusing on Drug Metabolizing Enzymes and Transporters, with Validated Methodology for CYP2D6 and CYP2C19 Including for a Novel Sub-Haplotype
DownloadSpring 2022
Pharmacogenomics (PGx) is interested in the impact individual genetic makeup has on a patient’s response to pharmacological agents. In clinical practice, PGx has the potential of reducing adverse drug reactions (ADRs), which cost Canada $65 million dollars in the year 2018, as well as enhancing...