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Fall 2019

Gomez, Daniela Isabel

Despite the wide availability of effective antiretroviral therapy (ART), neurocognitive problems persist in over 20% of people living with HIV. Neurocognitive problems are highly heterogeneous in HIV, and the underlying etiology of neurocognitive impairment (NCI) is multifactorial. The...

Spring 2019

Malik, Manoj K

Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...

Fall 2019

Benoit, James RA

The goal of this thesis is to contribute to the fields of data-driven medicine and computational psychiatry by attempting to demonstrate the viability of machine learning for use in psychiatry, specifically in predicting treatment outcomes for major depression. This is attempted in four ways: ...

Fall 2019

Necyk, Bradley W

Stories matter deeply. They help us see, experience, understand, and make meaning in our world and lives. As we will see in this dissertation, to create lasting positive social change, we need new stories, stories that reveal new paths, hopes, and futures. Art is a powerful storytelling medium,...

Fall 2018

Thomas, Rejish

Background Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant depression patients remains...

Spring 2018

Lodhi, Rohit J.

Patients who have a severe mental illness such as psychosis experience a greater burden in terms of poor physical and mental health outcomes or adverse health outcome/s (AHO). The etiological factors for AHO include the illness itself, medication side effects, poor diet and lifestyle, substance...

Spring 2017

Dametto, Ericson

Neurocysticercosis, the major global cause of acquired epilepsy, is a parasitic disease caused by Taenia solium larvae. Patients may have seizures whether larvae in brain are alive or degenerated (calcified). We assessed whether parasitic lesions produce changes in structural brain scans that are...

Spring 2017

Hamza, Deena M

Substance misuse in Canada is a major individual and public health issue, with evidence suggesting that in many cases it starts during youth. Reducing rates of misuse is therefore important. In 2013, an estimated 3.1 million Canadians over the age of 15 used at least one of 6 illicit substances...

Fall 2017

Sivapalan, Sudhakar

Background: The metabolic syndrome (MetS) is a cluster of biological parameters that have been identified as significant risk factors in the development of cardiovascular disease. The relevance of MetS to the psychiatric population has been demonstrated in that having severe mental illness (SMI)...

Fall 2017

Bhardwaj, Paramjit P

Variations in glutamate and γ-aminobutyric acid (GABA), excitatory and inhibitory amino acid neurotransmitters in the brain, have been linked with cyclical changes across the menstrual cycle and in stress and stress-related mental disorders. We used 3.0 Tesla proton magnetic resonance...