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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
- 1Armstrong, Jeff
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Computational psychiatry: machine learning for clinical decision support in the treatment of major depression
DownloadFall 2019
The goal of this thesis is to contribute to the fields of data-driven medicine and computational psychiatry by attempting to demonstrate the viability of machine learning for use in psychiatry, specifically in predicting treatment outcomes for major depression. This is attempted in four ways: ...
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Fall 2019
Stories matter deeply. They help us see, experience, understand, and make meaning in our world and lives. As we will see in this dissertation, to create lasting positive social change, we need new stories, stories that reveal new paths, hopes, and futures. Art is a powerful storytelling medium,...
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Rapid effectiveness of intravenous ketamine for ultraresistant depression in a clinical setting and evidence for baseline anhedonia and bipolarity as clinical predictors of effectiveness
DownloadFall 2018
Background Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant depression patients remains...
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Spring 2018
Patients who have a severe mental illness such as psychosis experience a greater burden in terms of poor physical and mental health outcomes or adverse health outcome/s (AHO). The etiological factors for AHO include the illness itself, medication side effects, poor diet and lifestyle, substance...
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Spring 2017
Cannabis use is a known risk factor for the development of psychotic disorders. Clinical and preclinical genetic studies provide growing evidence that genes related to dopamine signalling and neuroprotection, like COMT, are implicated in the cannabis-psychosis association. Considering the burden...
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Spring 2017
Neurocysticercosis, the major global cause of acquired epilepsy, is a parasitic disease caused by Taenia solium larvae. Patients may have seizures whether larvae in brain are alive or degenerated (calcified). We assessed whether parasitic lesions produce changes in structural brain scans that are...
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Possible effectiveness of a novel multimodal school-based program, EMPATHY, to reduce substance misuse in youth: A mixed methods intervention
DownloadSpring 2017
Substance misuse in Canada is a major individual and public health issue, with evidence suggesting that in many cases it starts during youth. Reducing rates of misuse is therefore important. In 2013, an estimated 3.1 million Canadians over the age of 15 used at least one of 6 illicit substances...
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Non-verbal cognitive domain functions positively associate with mildly elevated fasting blood glucose in individuals presenting with a psychotic illness
DownloadFall 2017
Background: The metabolic syndrome (MetS) is a cluster of biological parameters that have been identified as significant risk factors in the development of cardiovascular disease. The relevance of MetS to the psychiatric population has been demonstrated in that having severe mental illness (SMI)...
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Variation in in vivo prefrontal GABA, glutamate and glutamine – effects of reproductive factors, cortisol and major depressive disorder
DownloadFall 2017
Variations in glutamate and γ-aminobutyric acid (GABA), excitatory and inhibitory amino acid neurotransmitters in the brain, have been linked with cyclical changes across the menstrual cycle and in stress and stress-related mental disorders. We used 3.0 Tesla proton magnetic resonance...
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The role of β-amyloid peptides in kainic acid-induced toxicity and its implications in Mesial Temporal Lobe Epilepsy
DownloadFall 2017
Kainic acid is a non-degradable analogue of the excitatory neurotransmitter glutamate that, when injected systemically into adult rats, can trigger seizures and progressive neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (MTLE), most prevalent form...