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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Adu, Medard Kofi
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
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Fall 2009
In rodents, stress and corticosteroids rapidly increase excitatory neurotransmission. During excitatory neurotransmission, glutamate concentrations are maintained by conversion of glutamine to glutamate. The hypothesis was that cortisol would alter human prefrontal glutamine or glutamate...
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Adult Education to Help Reduce Child Sexual Abuse: Developing Novel Classroom and Online Approaches Designed to Change Knowledge, Attitudes, and Behaviours
DownloadFall 2016
Child sexual abuse (CSA) is common and individuals who experience CSA have higher rates of psychopathology and higher risk of medical, psychological, behavioural, and sexual disorders than those who have not been sexually abused. Adults who interact with children are in ideal positions to reduce...
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Rapid effectiveness of intravenous ketamine for ultraresistant depression in a clinical setting and evidence for baseline anhedonia and bipolarity as clinical predictors of effectiveness
DownloadFall 2018
Background Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant depression patients remains...
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Spring 2011
Self-harming behaviours and suicidality are a serious problem in psychiatric patients with major depressive disorder (MDD) and borderline personality disorder (BPD). Suicidal behaviours are sometimes seen as manipulative and attention-seeking in BPD patients, and are therefore not considered as...
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Possible effectiveness of a novel multimodal school-based program, EMPATHY, to reduce substance misuse in youth: A mixed methods intervention
DownloadSpring 2017
Substance misuse in Canada is a major individual and public health issue, with evidence suggesting that in many cases it starts during youth. Reducing rates of misuse is therefore important. In 2013, an estimated 3.1 million Canadians over the age of 15 used at least one of 6 illicit substances...
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Non-verbal cognitive domain functions positively associate with mildly elevated fasting blood glucose in individuals presenting with a psychotic illness
DownloadFall 2017
Background: The metabolic syndrome (MetS) is a cluster of biological parameters that have been identified as significant risk factors in the development of cardiovascular disease. The relevance of MetS to the psychiatric population has been demonstrated in that having severe mental illness (SMI)...
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Neurochemical and neuroprotective aspects of phenelzine and its active metabolite B-phenylethylidenehydrazine
DownloadFall 2009
Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor that also inhibits the activity of GABA-transaminase (GABA-T), causing significant and long-lasting increases in brain GABA levels. Inhibition of MAO prior to PLZ administration has been shown to prevent the GABAergic effects of the drug,...