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- 1Abou Marak Dit Roum, Darine
- 1Aguilar, Hector N
- 1Al-Momany, Abass M T
- 1Al-Zubaidy, Zaidoon A.
- 1Aljunaidy, Mais
- 1Almomani, Ensaf Y
Intracellular pH was monitored at the cytosolic surface of plasma membrane solute transporters (Na+/H+/nucleoside co-transporters, or Cl-/HCO3- exchangers), using pH-sensitive fluorescent proteins (FPs), dual emission green FP (deGFP4) and a monomeric red FP Nectarine (mNect), whose development...
Introduction: Congenital Diaphragmatic Hernia (CDH), is a birth defect that occurs in approximately 1 in every 3,000 births. It arises when the diaphragm fails to form properly during development leaving a hole in the muscle. In utero, the abdominal contents protrude through hole, taking up...
Tumor necrosis factor triggers the expression and activation of matrix metalloproteinases through NADPH-dependent superoxide productionDownload
Tumor necrosis factor (TNF) is upregulated in a number of cardiomyopathies. This thesis investigates TNF in triggering the expression and activation of matrix metalloproteinases (MMPs) in pressure overload cardiac disease, and explores the role of superoxide. Cardiac pressure overload was...
Treating the Placenta with a Nanoparticle-Encapsulated Mitochondrial Antioxidant Improves Placental Function and Fetal Cardiomyocyte Development in a Rat Model of Prenatal HypoxiaDownload
Introduction: Pregnancy complications associated with prenatal hypoxia have been linked to the development of cardiovascular disease in adult offspring. Prenatal hypoxia (due to maternal or placental hypoxia) has been shown to increase placental oxidative stress and impair placental function in a...
Arsenic is a potent environmental contaminant and human carcinogen, occurring naturally in the earth’s crust and entering the food chain through leeching into the water supply. Upon entering the body, inorganic arsenic is methylated to mono- and di-methylated forms, the trivalent versions of...
Therapies for preeclampsia and fetal growth restriction: restoration of uterine blood flow tested in mouse modelsDownload
Preeclampsia (PE) and fetal growth restriction (FGR) complicate over 10% of human pregnancies and contribute significantly to fetal and maternal morbidity and mortality. Although the causes of PE and FGR are not well understood, they are known to be associated with impaired uterine artery blood...
The proximal tubule (PT) is a major site of paracellular transport. Research in this area is undermined by the lack of a model system that is representative of PT electrophysiology. We examined opossum kidney (OK) cell characteristics and found a striking resemblance to the PT (transepithelial...