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Spring 2024

Zadunayski, Tanis K

Abstract Background: During the COVID-19 pandemic, health care workers (HCW) were at risk of SARS-CoV-2 infection and of developing a post-COVID condition (PCC). Post-COVID conditions are generally defined to occur following the onset of COVID-19, be present after 3 months, and persist for at...

Spring 2024

Weyant, Robert Benson

Background: The Human Microbiome is an area of increasing interest, both in and outside of the scientific community. While overall knowledge has increased exponentially, many aspects remain unclear, such as mechanisms of host-interaction and persistence. Intracellular bacteria have previously...

Spring 2024

Alghbli, Salem

Abstract Advanced cirrhosis is characterized by hemodynamic abnormali􀆟es, including increased portal pressure, and decreased arterial pressure, which contribute to the complica􀆟ons of the disease4. Short chain faty acids (SCFAs), produced by the gut microbiota through carbohydrate fermenta􀆟on,...

Spring 2024

Lai, Justine M.Y.

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy associated with a poor clinical outcome that is largely attributed to disease relapses. Treatment options for relapsed AML patients are limited; after relapse, the median survival is only ~6 months. The biology underlying...

Spring 2024

Babadagli, Hazal

Background: Rural patients have been shown to have reduced access to care, delayed discharge prescription fills, and frequent readmissions following acute coronary syndrome (ACS) compared to urban patients. While virtual and pharmacist-led programs have shown benefit in providing efficient care...

Spring 2024

Asadi, Leyla

This thesis, comprising three published research papers, examines both Canada's tuberculosis (TB) surveillance strategies among foreign-born individuals and broader TB transmission dynamics. In Canada, a country with low TB incidence, most TB cases occur among the foreign-born population. The...

Spring 2024

Basonbul, Asmaa A.

Temozolomide (TMZ) is an alkylating agent with limited activity in acute myeloid leukemia (AML). The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) enhances tumor cell resistance to TMZ. B-cell lymphoma-2 (BCL-2) and mouse double minute 2 homology (MDM2) are proteins involved in AML...

Spring 2023

Poursharif, Shayan

Kidneys stabilize renal blood flow (RBF) in response to fluctuations in blood pressure by employing two mechanisms, the myogenic response (MR) and the tubuloglomerular feedback (TGF) mechanism. The TGF mechanism stabilizes macula densa solute delivery via controlling afferent arteriolar diameter....

Spring 2023

Ismond, Kathleen P

Rapid adoption of internet-connected technology (ICT) by society has supported an unprecedented rate of change in hardware, software, and connectivity making the technology more accessible and user friendly. In turn, the application of this technology has reshaped how people communicate, acquire...

Spring 2023

Mast, Heather

Background: Mitochondrial dysfunction is a recognized hallmark of aging that is also directly or indirectly connected to practically all the other hallmarks of aging. As a result, mitochondrial dysfunction seems to be an important regulator of lifespan. Many studies provide evidence of lifespan...