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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Depression
- 4Endothelial cells
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Does 18F-Fluodordeoxyglucose Positron Emission Tomography (PET) Correlate with Disease Activity in Patients who are Receiving Treatment for Giant Cell Arteritis (GCA): a Systematic Review and Meta-Analysis.
DownloadSpring 2023
Introduction: The utility of obtaining follow up 18-F fluorodeoxyglucose positron emission tomography (FDG PET) imaging in patients with giant cell arteritis (GCA) is unclear. We performed a systematic review and meta-analysis to determine how often vascular FDG PET uptake improves or normalizes...
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In silico analysis of changes in predicted metabolic capabilities of intestinal microbiota after fecal microbial transplantation for treatment of recurrent Clostridioides difficile infection
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Importance: Fecal microbial transplantation (FMT) is effective in treating recurrent Clostridioides difficile (RCDI) infection. The therapeutic efficacy of FMT is thought to be related to restoration of intestinal microbial composition and diversity and key microbially derived compounds, such as...
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N6-methyladenosine bimodal peak signature mediates acute and selective stress translation by specialized cytoskeletal ribosomes via a MARK4-FTO-PKR axis
DownloadSpring 2023
Cellular responses to stress are temporally-organized complex pathways designed to prioritize resources and adapt in order to promote repair and survival. In severe stress, the energetically demanding mRNA translation is mostly inhibited, but it is not known whether there is a universal mechanism...
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Spring 2023
Rapid adoption of internet-connected technology (ICT) by society has supported an unprecedented rate of change in hardware, software, and connectivity making the technology more accessible and user friendly. In turn, the application of this technology has reshaped how people communicate, acquire...
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A Review of the Appropriate Usage and Efficacy of Iron Replacement Therapy in Gastroenterology Inpatients: Is Intravenous Iron Overutilized?
DownloadSpring 2023
Background: Iron deficiency anemia (IDA) is highly prevalent in patients with gastrointestinal disease. Therefore, appropriate replacement therapy is an essential component of management. Both intravenous (IV) and oral (PO) iron replacement therapies (IRT) are effective. There are concerns,...
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Functional Assessment on the Differential Effect of Mutant p53-Plakoglobin Interaction in Carcinoma Cells
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p53 transcriptional factor and tumor suppressor protein is mutated in over 50% of all cancers and most metastatic tumors. Majority of p53 mutations are single missense mutation and occur in the DNA-binding domain (DBD). The six most common missense mutations in the p53 DBD are known as “hot...
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Specific reduction in complex I of the mitochondrial electron transport system in long-lived seed beetles
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Background: Mitochondrial dysfunction is a recognized hallmark of aging that is also directly or indirectly connected to practically all the other hallmarks of aging. As a result, mitochondrial dysfunction seems to be an important regulator of lifespan. Many studies provide evidence of lifespan...
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Impact of Inherited Bleeding Disorders and Iron Deficiency Anemia on Maternal Bleeding and Other Pregnancy Outcomes: A Population-based Cohort Study from Alberta, Canada
DownloadSpring 2023
Background: Inherited bleeding disorders are caused by quantitative and qualitative alterations of coagulation proteins or platelets involved in hemostasis. The most frequent inherited bleeding disorders are hemophilia, von Willebrand disease (VWD) and inherited platelet function disorder. Women...
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Impact of changes in proximal tubular reabsorption on kidney function and on blood flow synchronization among nephrons
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Kidneys stabilize renal blood flow (RBF) in response to fluctuations in blood pressure by employing two mechanisms, the myogenic response (MR) and the tubuloglomerular feedback (TGF) mechanism. The TGF mechanism stabilizes macula densa solute delivery via controlling afferent arteriolar diameter....
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Spring 2023
Introduction: Acute kidney injury (AKI) is associated with significant morbidity and mortality. It affects approximately 4 to 7% of hospitalizations each year with a reported annual increase of 10% in incidence. Many studies have relied on administrative diagnostic codes to describe temporal...