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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 8Primary Biliary Cholangitis
- 7Inflammatory Bowel Disease
- 7Inflammatory bowel disease
- 6Endothelial cells
- 5Acute myeloid leukemia
- 5Mitochondria
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N6-methyladenosine bimodal peak signature mediates acute and selective stress translation by specialized cytoskeletal ribosomes via a MARK4-FTO-PKR axis
DownloadSpring 2023
Cellular responses to stress are temporally-organized complex pathways designed to prioritize resources and adapt in order to promote repair and survival. In severe stress, the energetically demanding mRNA translation is mostly inhibited, but it is not known whether there is a universal mechanism...
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Evaluating Novel Prognostic Markers and Preventative Therapies for Chronic Lung Allograft Dysfunction after Lung Transplantation
DownloadFall 2023
Introduction: Survival following lung transplantation remains limited by chronic lung allograft dysfunction (CLAD). Few therapeutic options have been shown to be effective in established CLAD thus early detection and prevention are key. Objective: We aimed to identify potential early prognostic...
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A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in Patients Undergoing Pharmaco-invasive Reperfusion Early After an ST-segment Elevation Myocardial Infarction
DownloadFall 2023
Background: N-acetyl cysteine (NAC) effectively breaks down arterial thrombi in animal models and activates cardioprotective cellular pathways in STEMI models. Our study aimed to conduct a pilot trial to translate the beneficial effects of intravenous NAC observed in vascular occlusion models...
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Implementing and Evaluating Virtual Mindfulness-Based Stress Reduction for Adults with Inflammatory Bowel Disease
DownloadFall 2023
Inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis, are chronic diseases of the gastrointestinal tract. Individuals living with IBD suffer from chronic symptoms of fatigue and malnutrition and unpredictable flares of acute symptoms including abdominal pain,...
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The Impact Of Colonization by Multi Drug Resistant Bacteria on Graft Survival, Risk of Infection, and Mortality in Recipients of Solid Organ Transplant: Systematic Review and Meta-analysis
DownloadFall 2023
Background: Colonization with multi-drug resistant bacteria (MDR) in solid organ transplant (SOT) recipients increases the risk of post-transplant bacterial infection. The impact of MDR colonization on graft survival and mortality is not well established. Methods: We searched PROSPERO, OVID...
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Use of Guideline-directed Medical Therapy in Patients ≥65 years after the Diagnosis of Heart Failure: A Canadian Population-based Study
DownloadFall 2023
Background: Guideline-directed medical therapy (GDMT) improves clinical outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Despite proven efficacy, GDMT are under-utilized in clinical practice. The current study examines GDMT utilization after incident...
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Functional Assessment on the Differential Effect of Mutant p53-Plakoglobin Interaction in Carcinoma Cells
DownloadSpring 2023
p53 transcriptional factor and tumor suppressor protein is mutated in over 50% of all cancers and most metastatic tumors. Majority of p53 mutations are single missense mutation and occur in the DNA-binding domain (DBD). The six most common missense mutations in the p53 DBD are known as “hot...
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The metabolic basis of cell identity in the pulmonary arteries and the right ventricle in pulmonary arterial hypertension
DownloadFall 2023
Pulmonary arterial hypertension (PAH) is an incurable disease characterized by profound pulmonary vascular remodeling, including the development of plexogenic lesions (which is the hallmark of PAH) that results in lumen obliteration, raising the pulmonary vascular resistance (PVR) and the right...
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Specific reduction in complex I of the mitochondrial electron transport system in long-lived seed beetles
DownloadSpring 2023
Background: Mitochondrial dysfunction is a recognized hallmark of aging that is also directly or indirectly connected to practically all the other hallmarks of aging. As a result, mitochondrial dysfunction seems to be an important regulator of lifespan. Many studies provide evidence of lifespan...
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In silico analysis of changes in predicted metabolic capabilities of intestinal microbiota after fecal microbial transplantation for treatment of recurrent Clostridioides difficile infection
DownloadSpring 2023
Importance: Fecal microbial transplantation (FMT) is effective in treating recurrent Clostridioides difficile (RCDI) infection. The therapeutic efficacy of FMT is thought to be related to restoration of intestinal microbial composition and diversity and key microbially derived compounds, such as...