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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 8Primary Biliary Cholangitis
- 7Inflammatory Bowel Disease
- 7Inflammatory bowel disease
- 6Endothelial cells
- 5Acute myeloid leukemia
- 5Mitochondria
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Specific reduction in complex I of the mitochondrial electron transport system in long-lived seed beetles
DownloadSpring 2023
Background: Mitochondrial dysfunction is a recognized hallmark of aging that is also directly or indirectly connected to practically all the other hallmarks of aging. As a result, mitochondrial dysfunction seems to be an important regulator of lifespan. Many studies provide evidence of lifespan...
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Impact of Inherited Bleeding Disorders and Iron Deficiency Anemia on Maternal Bleeding and Other Pregnancy Outcomes: A Population-based Cohort Study from Alberta, Canada
DownloadSpring 2023
Background: Inherited bleeding disorders are caused by quantitative and qualitative alterations of coagulation proteins or platelets involved in hemostasis. The most frequent inherited bleeding disorders are hemophilia, von Willebrand disease (VWD) and inherited platelet function disorder. Women...
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Evaluating Novel Prognostic Markers and Preventative Therapies for Chronic Lung Allograft Dysfunction after Lung Transplantation
DownloadFall 2023
Introduction: Survival following lung transplantation remains limited by chronic lung allograft dysfunction (CLAD). Few therapeutic options have been shown to be effective in established CLAD thus early detection and prevention are key. Objective: We aimed to identify potential early prognostic...
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The Impact Of Colonization by Multi Drug Resistant Bacteria on Graft Survival, Risk of Infection, and Mortality in Recipients of Solid Organ Transplant: Systematic Review and Meta-analysis
DownloadFall 2023
Background: Colonization with multi-drug resistant bacteria (MDR) in solid organ transplant (SOT) recipients increases the risk of post-transplant bacterial infection. The impact of MDR colonization on graft survival and mortality is not well established. Methods: We searched PROSPERO, OVID...
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N6-methyladenosine bimodal peak signature mediates acute and selective stress translation by specialized cytoskeletal ribosomes via a MARK4-FTO-PKR axis
DownloadSpring 2023
Cellular responses to stress are temporally-organized complex pathways designed to prioritize resources and adapt in order to promote repair and survival. In severe stress, the energetically demanding mRNA translation is mostly inhibited, but it is not known whether there is a universal mechanism...
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Spring 2023
Patients with atrial fibrillation (AF) and ischemic stroke are at high risk for stroke recurrence. Early anticoagulation may reduce the risk of recurrent events but is usually avoided due to the risk of hemorrhagic transformation (HT). The risk of HT is based on historical data from an older...
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Fall 2023
Angiogenesis, the process of forming new blood vessels from a pre-exciting vasculature, is an essential component of embryonic development, tissue remodelling, wound healing, and tumor growth. This process is strictly regulated by a vast array of cellular signalling pathways involving kinases,...
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Does 18F-Fluodordeoxyglucose Positron Emission Tomography (PET) Correlate with Disease Activity in Patients who are Receiving Treatment for Giant Cell Arteritis (GCA): a Systematic Review and Meta-Analysis.
DownloadSpring 2023
Introduction: The utility of obtaining follow up 18-F fluorodeoxyglucose positron emission tomography (FDG PET) imaging in patients with giant cell arteritis (GCA) is unclear. We performed a systematic review and meta-analysis to determine how often vascular FDG PET uptake improves or normalizes...
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A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in Patients Undergoing Pharmaco-invasive Reperfusion Early After an ST-segment Elevation Myocardial Infarction
DownloadFall 2023
Background: N-acetyl cysteine (NAC) effectively breaks down arterial thrombi in animal models and activates cardioprotective cellular pathways in STEMI models. Our study aimed to conduct a pilot trial to translate the beneficial effects of intravenous NAC observed in vascular occlusion models...
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Use of Guideline-directed Medical Therapy in Patients ≥65 years after the Diagnosis of Heart Failure: A Canadian Population-based Study
DownloadFall 2023
Background: Guideline-directed medical therapy (GDMT) improves clinical outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Despite proven efficacy, GDMT are under-utilized in clinical practice. The current study examines GDMT utilization after incident...