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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 8Primary Biliary Cholangitis
- 7Inflammatory Bowel Disease
- 7Inflammatory bowel disease
- 6Endothelial cells
- 5Acute myeloid leukemia
- 5Mitochondria
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Spring 2018
Renal cell carcinoma comprises approximately 2-3% of all malignancies, with the majority, approximately 70%, being clear cell renal cell carcinoma (ccRCC). ccRCC features many cancer hallmarks such as suppressed mitochondrial glucose oxidation, apoptosis-resistance, angiogenesis, immune evasion,...
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Immune activation in patients with admission blood pressure above 185/110 mm Hg in acute ischemic stroke
DownloadFall 2021
Background: An admission blood pressure over 185/110 mm Hg is associated with increased risk of recombinant tissue plasminogen activator (r-tPA)-related hemorrhagic transformation (HT). Stroke guidelines recommend blood pressure (BP) above 185/110 mm Hg be lowered before r-tPA treatment. How high...
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A Reversible Metabolic Stress-Sensitive Regulation of Collapsin Response Mediator Protein 2A Orchestrates Cytoskeletal Remodeling and EMT, Increasing Metastatic Potential in Cancer
DownloadFall 2021
Cancer represents the second leading cause of death globally only after heart disease and is responsible for about 10 million deaths per year with a significant economic impact (WHO facts). Moreover, its prevalence is projected to increase over the following decades. Among all cancers, breast,...
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A Discrete Choice Experiment Pilot Study: Understanding Patient Preferences for In-centre Hemodialysis
DownloadFall 2021
Background: End-stage kidney disease (ESKD) is the failure of functioning kidneys such that they no longer have the capacity to sustain life without intervention. While the incidence of ESKD has remained generally stable across all ages of Canadians since 2000, the prevalence of ESKD has been...
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Severe cholestasis during the first year post-transplant predicts primary sclerosing cholangitis recurrence
DownloadFall 2021
Background Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease of unknown etiology, whose only definitive management is liver transplantation. One of the dilemmas that PSC patients face is the recurrence of the disease in the graft, which may shorten the organ’s life expectancy...
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A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in Patients Undergoing Pharmaco-invasive Reperfusion Early After an ST-segment Elevation Myocardial Infarction
DownloadFall 2023
Background: N-acetyl cysteine (NAC) effectively breaks down arterial thrombi in animal models and activates cardioprotective cellular pathways in STEMI models. Our study aimed to conduct a pilot trial to translate the beneficial effects of intravenous NAC observed in vascular occlusion models...