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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 8Primary Biliary Cholangitis
- 7Inflammatory Bowel Disease
- 7Inflammatory bowel disease
- 6Endothelial cells
- 5Acute myeloid leukemia
- 5Mitochondria
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Spring 2024
Abstract Advanced cirrhosis is characterized by hemodynamic abnormalies, including increased portal pressure, and decreased arterial pressure, which contribute to the complicaons of the disease4. Short chain faty acids (SCFAs), produced by the gut microbiota through carbohydrate fermentaon,...
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Deciphering the Biological Basis of Acute Myeloid Leukemia Relapse Using a Novel In-Vitro Study Model
DownloadSpring 2024
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy associated with a poor clinical outcome that is largely attributed to disease relapses. Treatment options for relapsed AML patients are limited; after relapse, the median survival is only ~6 months. The biology underlying...
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Pharmacist-Led Follow-Up Program for Rural Acute Coronary Syndrome Patients: The PLURAL-ACS Study
DownloadSpring 2024
Background: Rural patients have been shown to have reduced access to care, delayed discharge prescription fills, and frequent readmissions following acute coronary syndrome (ACS) compared to urban patients. While virtual and pharmacist-led programs have shown benefit in providing efficient care...
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An assessment of Canada’s foreign-born tuberculosis surveillance strategy and insights gained into TB transmission
DownloadSpring 2024
This thesis, comprising three published research papers, examines both Canada's tuberculosis (TB) surveillance strategies among foreign-born individuals and broader TB transmission dynamics. In Canada, a country with low TB incidence, most TB cases occur among the foreign-born population. The...
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Evaluation of Targeted Selective Inhibitors to Enhance Temozolomide Treatment Sensitivity in Acute Myeloid Leukemia
DownloadSpring 2024
Temozolomide (TMZ) is an alkylating agent with limited activity in acute myeloid leukemia (AML). The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) enhances tumor cell resistance to TMZ. B-cell lymphoma-2 (BCL-2) and mouse double minute 2 homology (MDM2) are proteins involved in AML...
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The metabolic basis of cell identity in the pulmonary arteries and the right ventricle in pulmonary arterial hypertension
DownloadFall 2023
Pulmonary arterial hypertension (PAH) is an incurable disease characterized by profound pulmonary vascular remodeling, including the development of plexogenic lesions (which is the hallmark of PAH) that results in lumen obliteration, raising the pulmonary vascular resistance (PVR) and the right...
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Studying Systemic Metabolic Remodeling and Abnormal Mitochondrial Signaling in Primary Biliary Cholangitis
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Primary biliary cholangitis (PBC) is linked with the production of anti-mitochondrial antibodies (AMA) targeting pyruvate dehydrogenase complex-E2 subunit (PDC-E2). Cholangiocytes from PBC patients express increased PDC-E2, which is thought to result in loss of tolerance to mitochondrial...
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Fall 2024
Background: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Patients with CKD and CVD are often excluded from randomized control trials leading to a paucity of evidence guiding their care. This study leveraged province-wide...
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Fall 2024
The neighbourhood food environment, defined as the exposure to (measured as availability, density, or distance to) healthy and unhealthy food outlets around places within which individuals gravitate, including home, schools, workplaces, and beyond, plays a complex role in influencing food intake...
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Preventable errors in the performance and reporting of echocardiography and right heart catheterization can lead to diagnosis errors for pulmonary hypertension with significant implications for patients
DownloadFall 2024
Pulmonary hypertension (PH) is common and PH subgroups have vastly different mortality and treatment, particularly pulmonary arterial hypertension (PAH) versus PH secondary to heart failure with preserved ejection fraction (HFpEF). Both transthoracic echocardiography (TTE) and right heart...