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Skip to Search Results- 33Mass-spectrometry
- 29Chemistry
- 23Organic compounds. Synthesis.
- 22Catalysis
- 22Metabolomics
- 21Capillary electrophoresis.
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Spring 2012
Tuberculosis is a contagious disease, caused by Mycobacterium tuberculosis. Harsh requirements required to treat tuberculosis result from the structure of the mycobacterial cell wall. Lipoarabinomannan, an important component and major antigen of the cell wall, is able to modulate the host immune...
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Fall 2020
Over the coming decades, global population and energy consumption are projected to increase dramatically, with the latter doubling by 2050 as per the most conservative estimates. Much of this demand is likely to be met with increased use of fossil fuels. The burning of fossil fuels is a major...
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Fall 2012
Thuricin CD, a two-component bacteriocin produced by Bacillus thuringiensis DPC 6431, exhibits potent activity against the hospital superbug Clostridium difficile ribotype O27. The two peptides (Trn-α and Trn-β) that constitute thuricin CD operate synergistically to kill sensitive bacteria at...
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Fall 2014
Oxime ligation is an effective conjugation strategy for biomolecules and polymers in aqueous solution. The reaction is chemoselective, joining an aldehyde or ketone electrophile with an aminooxy nucleophile. The oxime linkage is thermally and hydrolytically stable under most biological...
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Spring 2013
The number of biologically important events mediated by carbohydrates has generated great interest in the synthesis of oligosaccharides and the development of new methods for glycosidic bond formation. I have developed a glycosylation method where glycosyl donors containing a three-membered...