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- 2Li, Leo
- 2Nizio, Katie D
- 1Abdel Latif Ibraheem, Ahmed Abdel Mohsen
- 1Abdelfattah, Ahmed
- 1Abel, Robin Jacob
- 1Abou-Ghanem, Maya
- 23Organic compounds. Synthesis.
- 21Capillary electrophoresis.
- 18Chemical reactions.
The overall goal of this thesis research is to develop a spectral searching strategy capable of identifying peptide sequences from MS/MS spectra with high sensitivity and accuracy. First, a shotgun proteome analysis method was developed and successfully applied to the identification of proteins...
Thuricin CD, a two-component bacteriocin produced by Bacillus thuringiensis DPC 6431, exhibits potent activity against the hospital superbug Clostridium difficile ribotype O27. The two peptides (Trn-α and Trn-β) that constitute thuricin CD operate synergistically to kill sensitive bacteria at...
The presence of complex polycyclic skeletons is a commonly encountered phenomenon in natural products and biologically active compounds. Having diverse synthetic approaches for accessing them is vital for the effective development of the pharmaceutical industry. Among other strategies, pericyclic...
Mechanism of iodine-catalyzed multicomponent cyclocondensation reactions: Synthesis of polysubstituted quinoline "archipelago" asphaltene mimicsDownload
Asphaltenes constitute the heaviest and least understood sub-class of bitumen. The degree of difficulty regarding upgrading arises from the diverse and complex mixture of organic and organometallic molecules characteristic of heavy petroleum. It is hypothesized that these molecular constituents...
Investigation of the biosynthesis of lovastatin and cytochalasin E, two fungal polyketides assembled by iterative PKS-NRPS enzymesDownload
Cytochalasin E and lovastatin are two fungal polyketides that have seen extensive use as an angiogenesis inhibitor and as a cholesterol-lowering agent, respectively. These structurally divergent compounds are synthesized by polymerization of acetate units with concomitant functionalization by two...