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- 2Li, Leo
- 2Nizio, Katie D
- 1Abdel Latif Ibraheem, Ahmed Abdel Mohsen
- 1Abdelfattah, Ahmed
- 1Abel, Robin Jacob
- 1Abou-Ghanem, Maya
- 23Organic compounds. Synthesis.
- 21Capillary electrophoresis.
- 18Chemical reactions.
The first chapter of this thesis represents the continued development of a general method for the formation of benzo-fused N-heterocycles by formal radical cyclization onto benzene rings. Important stages in this process involve 1) the copper-mediated coupling of various amino alcohols to...
As the endpoint of the “omics” cascade, metabolomics has attracted much attention in the discovery of diagnostic or prognostic disease biomarkers, and as a powerful tool to understand biological and biochemical processes and mechanisms. The objective of my research was to develop a highly...
Interest in microfluidic platforms has surged as an alternative for sample preparation in the past two decades, with the potential for miniaturization, portability, automation, integration and parallelism driving this research. However, it is still very challenging to develop an integrated...
Rosette nanotubes (RNTs) are bio-inspired nanomaterials generated from the self-assembly of a guanine-cytosine motif called the “G∧C” base. These nanotubular architectures are promising 2-D coating materials for bone tissue engineering applications, and delivery scaffolds for hydrophobic drug...
Quantum Chemical Investigations of Structural and Photophysical Properties of Emissive RNA Nucleobase AnaloguesDownload
The photostability of nucleic acid constituents is crucial in maintaining the integrity of our genetic code. This is achieved by the essential mechanism of ultrafast radiationless decay of the singlet excited state to the electronic ground state of nucleobases. While this mechanism provides...
Cancer remains to be one of the deadliest diseases world-wide due to its effect on millions of lives per year. The discovery of RNA interference and delivery of siRNA (small-interfering RNA) for protein silencing have been widely used for treatment of cancer cells. Research in our lab focuses on...
Preparation of Optically Enriched Allylic Heterocyclic Organoboronates and Their Application in the Efficient Synthesis of Biologically Active CompoundsDownload
Organic chemistry is, has been, and will remain, a reliable tool for creating nearly any target molecule. Modern organic synthesis, however, is leaning towards the themes of efficiency, selectivity and strategy. In the midst of a potential energy crisis and global resource shortage, the primary...