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- 2Veldhoen, Richard
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Andrin, Christi.
- 1Arnason, Terra Gayle.
In Canada, approximately 40% of the population will be diagnosed with cancer and 25% will die of this disease. In order to treat cancer more effectively, new prognostic and therapeutic targets need to be discovered. In breast cancer, the BH3 only protein BAD has been shown to correlate with...
Approximately one third of the E. coli and human proteomes consist of membrane proteins. Among these proteins are oxidoreductases, which fulfil central roles in the bioenergetic processes of cells, function as pathogenicity factors in microorganisms and their dysfunction is responsible for many...
Herpes Simplex Virus Type 1 (HSV-1) establishes latent infections in neurons in vivo and lytic infections in epithelial cells and fibroblasts. During latent infections, HSV-1 transcription is restricted and the genomes are not replicated. Latent HSV-1 genomes are chromatinized, such that...
Molecular Mechanisms Underlying the Regulation of Protein Phosphatase-1c by the Apoptotic Stimulating Proteins of p53Download
Protein phosphatase-1c (PP-1c) is a ubiquitous serine/threonine protein phosphatase regulated in part by association with a large number of different regulatory subunits. Apoptotic Stimulating Proteins of p53 (ASPPs) are a family of proteins that regulate the apoptotic function of the tumour...
Systemic chemotherapy in combination with local intervention through surgery and radiotherapy are effective treatments for breast cancers. Chemotherapy is often used in patients with early signs of disease to effectively shrink the tumor and prevent metastasis before surgical excision of the...
Human cytomegalovirus (HCMV) infects 40–70% of the adult population in developed countries, and this rate increases with age. HCMV infection is normally latent with no noticeable symptoms in individuals with a healthy immune system. However, the infection can cause problems in immune-compromised...