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Developmental Programming of Cardiac and Coronary Artery Dysfunction in Adult Male and Female Offspring Exposed to Prenatal Hypoxia
DownloadSpring 2023
Cardiovascular disease is a leading cause of global mortality and a major contributor to morbidity worldwide. Early epidemiological studies demonstrated that pregnancy complications can impact the health of the offspring in adult life. Fetal hypoxia is one of the most common complications of...
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Fall 2022
Background: This thesis encompasses two distinct projects. 1) von Willebrand factor (VWF) is a highly adhesive multimeric glycoprotein found in the Weibel-Palade bodies of endothelial cells and in ⍺-granules of megakaryocytes and platelets. At the site of vascular injury, VWF is essential for...