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Fall 2010
Improving feed efficiency has become a top priority in beef cattle production because of the rapidly increasing cost of feed provision. However, because of the expense associated with collecting individual animal feed intake data, only a relatively small number of animals have been tested,...
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Regulation of Cardiac Gap Junctional Communication: Metabolic regulation of Cx40 and Cx43 via phosphorylation
DownloadFall 2015
Alterations in myocardial metabolism and cardiac electrophysiology associated with structural heart disease generate lethal arrhythmias. Differential levels of energy (ATP) supply and demand are generated with structural heart disease that is expected to activate 5’-amp activated protein kinase...
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Fall 2015
Polycystic kidney disease (PKD) protein 2 Like 1 (PKD2L1), also called transient receptor potential polycystin-3 (TRPP3), regulates Ca2+-dependent hedgehog signalling in primary cilia, intestinal development and sour tasting but with an unclear mechanism. PKD2L1 is a Ca2+-permeable cation channel...
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Spring 2012
Neuropathic pain afflicts 1.5-3% of the general population. It can be initiated by traumatic nerve injuries or diseases such as diabetic or post-herpetic neuropathy. Neuropathic pain is often initiated by abnormal spontaneous activity in sensory neurons and this provokes increased excitability of...
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Pharmacological and Fluorometric Assessment of Neuronal KCNQ Channels, and Implications for Understanding Neurological Disease
DownloadSpring 2020
Epilepsy affects 60 million people worldwide, and encompasses the most common forms of neurological disorders. Epilepsy manifests in diverse ways in patients, ranging from mild cognitive effects, to seizures, to the more severe epileptic encephalopathy. While many pharmacological approaches exist...
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Fall 2019
The development of efficacious anticancer therapies has significantly improved the prognosis of childhood cancer patients at the price of predisposing survivors to extensive chronic health problems. Although not fatal, reducing treatment-related hearing loss (ototoxicity) among childhood cancer...
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Spring 2017
Cannabis use is a known risk factor for the development of psychotic disorders. Clinical and preclinical genetic studies provide growing evidence that genes related to dopamine signalling and neuroprotection, like COMT, are implicated in the cannabis-psychosis association. Considering the burden...
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
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Application of genomics-based tools leading to the identification of markers on bovine chromosome 14 influencing milk production and carcass quality traits
DownloadFall 2009
Genetic improvements in beef and dairy cattle can bring significant advances in satisfying the global food demand, which is expected to double by 2050. Several DNA markers have been identified on bovine chromosome 14 (BTA14), but low mapping resolution prevents their refinement for identification...
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Spring 2014
Modifiable cardiovascular disease (CVD) risk factors, such as adiposity, are already associated with atherosclerotic progression in childhood. Less is known about whether physical activity (PA) is associated with progression of atherosclerosis in non-clinical samples of children. This...