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- 36Adults
- 17Randomized Controlled Trials as Topic
- 15Vitamin D
- 11Acute Disease
- 8Anti-Asthmatic Agents
- 40Graduate and Postdoctoral Studies (GPS), Faculty of
- 40Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 18Emergency Medicine, Department of
- 18Emergency Medicine, Department of/Reviews (Emergency Medicine)
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Fall 2014
Epidemiological studies correlate vitamin D deficiency with asthma severity. Calcitriol modulates receptor and cytokine expression from various leukocytes in an anti-inflammatory manner. Despite eosinophil activity during mucosal inflammation, knowledge on the direct effect of calcitriol on this...
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Vitamin D Supplementation and Bone Health in Adults with Diabetic Nephropathy: Preliminary Findings from a Randomized Controlled Trial
DownloadFall 2013
Vitamin D (vitD) is a nutrient of concern in Canada particularly for those with diabetes and chronic kidney disease (CKD). Participants (18-80y) with diabetes and CKD were randomized to receive either 50mcg/day (n=33) or 1,000mcg/month (n=30) vitD3 for 6-months. Variables studied included:...
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Vitamin D Status and Markers of Cardiometabolic and Liver Disease Risk in Childhood Obesity
DownloadSpring 2017
Vitamin D insufficiency is highly prevalent in children (up to 40%), particularly in northern climates such as Alberta, due to reduced sunlight exposure and low intake. Although suboptimal vitamin D status and metabolic dysregulation are commonly observed in obesity, little is known about the...
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Virus Induced Asthma Exacerbations: Immunologic Mechanisms and Metabolomic Biomarkers
2014-03-30
Asthma is a complex multifaceted chronic inflammatory disease that is characterized clinically by reversible airflow obstruction, shortness of breath, coughing, and wheezing. Asthma is the most common chronic disease in children, and is differentiated into many phenotypes with multiple triggers....
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Understanding the role of Clostridioides difficile and Vitamin D supplementation in shaping the gut microbiome of Canadian infants
DownloadSpring 2019
Introduction: The gut microbiome is shaped during infancy and has an important role in the development of both the immune and metabolic systems. Many early life exposures and events contribute to the composition of this complex intestinal environment, notably early infant diet and breastfeeding....
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Understanding implementation processes of clinical pathways and clinical practice guidelines in pediatric contexts: A study protocol
Download2011
Nettel-Aguirre, A., Klassen, T.P., Grimshaw, J., Johnson, D., Scott, S.
Background: Canada is among the most prosperous nations in the world, yet the health and wellness outcomes of Canadian children are surprisingly poor. There is some evidence to suggest that these poor health outcomes are partly due to clinical practice variation, which can stem from failure to...