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Skip to Search Results- 13Cryopreservation
- 9Articular cartilage
- 7Vitrification
- 4Chondrocytes
- 4Viability
- 3Cryoprotectant agents
- 11Chemical and Materials Engineering, Department of
- 11Chemical and Materials Engineering, Department of/Research Articles and Materials (Chemical and Materials Engineering)
- 11Graduate and Postdoctoral Studies (GPS), Faculty of
- 11Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 7Surgery, Department of
- 7Surgery, Department of/Orthopaedic Surgery
- 3Department of Chemical and Materials Engineering
- 3Department of Surgery
- 1Department of Civil and Environmental Engineering
- 1Department of Mathematical and Statistical Sciences
- 1Department of Physical Therapy
- 1Department of Renewable Resources
- 1Adesida, Adetola (Surgery)
- 1Adesida, Adetola B. (Surgery)
- 1Bagnall, Keith (Department of Surgery)
- 1Boluk, Yaman (Civil and Environmental Engineering)
- 1Elliott, Janet A. W. (Chemical & Materials Engineering and Laboratory Medicine & Pathology)
- 1Elliott, Janet A.W. (Chemical and Materials Engineering)
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2014-09-26
Rekieh, K., Abazari, A., Elliott, J.A., Jomha, N.M., Law, G.K., McGann, L.E.
Objective: Osteochondral allografting is an effective method to treat large osteochondral defects but difficulties in tissue preservation have significantly limited the application of this technique. Successful cryopreservation of articular cartilage (AC) could improve the clinical availability...
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2012
Elliott, J. A., Zhou, X., McGann, L. E., Adesida, A. B., Abazari, A., Law, G. K., Laouar, L., Forbes, J. F., Jomha, N. M., Maghdoori, B.
Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time....
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The role of cultured chondrocytes and mesenchymal stem cells in the repair of acute articular cartilage injuries
DownloadSpring 2010
Osteoarthritis (OA) is a disease that has significant individual, social, and economic impact worldwide. Although many etiologies lead to the eventual development of OA, one potentially treatable cause is the acute articular cartilage (AC) injury. These injuries are common and have a poor...
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Modeling the transport of cryoprotective agents in articular cartilage for cryopreservation
DownloadSpring 2011
Loading vitrifiable concentrations of cryoprotective agents is an important step for cryopreservation of biological tissues by vitrification for research and transplantation purposes. This may be done by immersing the tissue in a cryoprotective agent (CPA) solution, and increasing the...
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Versatile Polymer-Based Nanomedicines for Drug/Gene Delivery and Cell-based Therapy Applications
DownloadSpring 2021
Advances in polymer science and nanotechnology have allowed the development of biomaterials for cell-based applications, such as the delivery of a variety of drugs and genes, as well as supporting technologies, such as stem cell therapies, tissue engineering and cryopreservation. The progress in...
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2012
Law, G. K., Forbes, J. F., Elliott, J. A., McGann, L. E., Jomha, N. M., Prasad, V., Almansoori, K. A.
Background Vitrification is a method of cryopreservation by which cells and tissues can be preserved at low temperatures using cryoprotective agents (CPAs) at high concentrations (typically ⩾6.0 M) to limit the harmful effects of ice crystals that can form during cooling processes. However, at...
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Investigating cryoinjury using simulations and experiments: 1. TF-1 cells during two-step freezing (rapid cooling interrupted with a hold time)
Download2014-09-22
McGann, L. E., Ross-Rodriguez, L. U., Elliott, J. A.
There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me2SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the...
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Spring 2013
A major barrier to reclamation after oil sands mining is lack of commercially available, diverse native plant seeds and propagules for revegetation. Potential of LFH (forest floor material) developed on coarse textured soil for establishing native plants and how salvage, placement and storage...
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Fall 2015
Cryopreserving cells for human health therapeutics is a multidisciplinary process with great complexity. Cryopreservation of human umbilical vein endothelial cells (HUVECs) has facilitated vascular biology research since they were first isolated in 1973 [59]; however identifying key variables to...