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Skip to Search Results- 1Bartlett, Nathan T
- 1Collison, Breanne
- 1Cooper, Ian R
- 1Frieser, Emma CG
- 1Just, Timothy P
- 1Kruger, Calvin P
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Fall 2016
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and preclinical cognitive and memory decline in older adults. We investigated whether memory resilience to genetic risk (i.e., Apolipoprotein E [APOE] ɛ4, Clusterin [CLU] CC, and a high additive...
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Are Sex and Estrogen Modulators of Sympathetic Vascular Control in Resting and Contracting Skeletal Muscle?
DownloadSpring 2018
The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...
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Βeta-adrenergic receptors and opposition of evoked sympathetic vasoconstriction: Effects of sex and exercise training
DownloadFall 2016
Stimulation of the sympathetic nervous system evokes the release of neurotransmitters and produces vasoconstriction that is primarily mediated by the binding of norepinephrine (NE) to alpha-adrenergic receptors. However, NE may also bind to beta (β)-adrenergic receptors and produce vasodilation...
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Fall 2022
Contraction-mediated inhibition of sympathetic vasoconstriction (sympatholysis) is enhanced in female compared with male rats. Acute pharmacological blockade of nitric oxide (NO) production abolished the sex difference in sympatholysis, indicating that NO-mediated sympatholysis is elevated in...
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Does methylation of the brain promoter region of Cyp19 impact the development of sex-typical psychological traits?
DownloadFall 2017
While humans demonstrate sexually differentiated psychological and behavioural traits, such as aggression, there is a vast amount of within-sex variation for these traits. Further, the effect size of these sex differences is relatively small and there is a large amount of overlap between males...
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Spring 2022
Background: Carbon monoxide alters cardiovascular function through its actions as a signaling molecule and by limiting oxygen delivery in the blood, favouring pro-dilatory and anti-constrictor effects within the vasculature. The impacts of mild carbon monoxide exposure on vascular responses to...
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A Retrospective Analysis of the Safety and Efficacy of a 6-Week Pulmonary Rehabilitation Program in Patients with Severe Pulmonary Arterial Hypertension
DownloadSpring 2014
Pulmonary Arterial Hypertension (PAH) is progressive disease characterized by reduced exercise capacity and decreased quality of life. Despite the availability of disease targeted therapies outcomes remain sub-optimal. Pulmonary Rehabilitation has proven to improve outcomes in other chronic...