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Skip to Search Results- 12Graduate and Postdoctoral Studies (GPS), Faculty of
- 12Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 6Biological Sciences, Department of
- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Sustainable Forest Management Network
- 2Sustainable Forest Management Network/Project Reports (Sustainable Forest Management Network)
- 6Department of Mathematical and Statistical Sciences
- 2Department of Biological Sciences
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 1Department of Mechanical Engineering
- 1Department of Medical Microbiology and Immunology
- 2Li, Michael (Department of Mathematical and Statistical Sciences)
- 1Dr. Michael Li (Department of Mathematical and Statistical Sciences)
- 1Dr. Richard Long (School of Public Health and Department of Medicine)
- 1Feldman, Mario (Biological Sciences)
- 1Foley, Edan (Medical Microbiology and Immunology)
- 1Li, Michael (Mathematical and Statistical Sciences)
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Identification of Signaling Pathways Dysregulated during Scrapie Pathogenesis using a Kinomics Approach
DownloadSpring 2017
Prion diseases are a family of chronic lethal neurodegenerative diseases that affect humans and animals. The conversion of the cellular prion protein (PrPC) to abnormal conformations (PrPSc) is accepted to be required for pathogenesis. However, the molecular mechanisms whereby PrP conversion...
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The Effectiveness of Tuberculosis Control Strategies that Target Social Determinants of Health in Three First Nations and Métis Communities: A Mathematical Modeling Approach
DownloadFall 2017
BACKGROUND: Despite the overall decline in tuberculosis (TB) incidence in Canada, rates among Indigenous peoples have not decreased since the late 1990s. On-going transmission associated with the time from the onset of symptoms to treatment have been identified as major contributor to the...
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Parameter Estimation of Mathematical Models: Estimation of the Burden of HIV Epidemics as a Case Study
DownloadFall 2016
Mathematical models are widely used to describe dynamics in various fields. In practice, it is necessary and important to determine model parameters based on existing data. A major challenge for parameter estimation under modeling framework lies in non-identifiability issue: parameter values on a...
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Fall 2016
Understanding human immunodeficiency-1 (HIV-1) replication and latency in different reservoirs is an ongoing challenge in the care of patients with HIV/AIDS. A mathematical model was created that predicted HIV-1 and simian immunodeficiency virus (SIV) infection dynamics within the brain during...
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Rapid Increases in Forest Understory Diversity and Productivity following a Mountain Pine Beetle (Dendroctonus ponderosae) Outbreak in Pine Forests
Download2015-01-01
Pec, G. J., Karst, J., Sywenky, A. N, Cigan, P. W., Erbilgin, N., Simard, S. W., Cahill, J. F.
The current unprecedented outbreak of mountain pine beetle (Dendroctonus ponderosae) in lodgepole pine (Pinus contorta) forests of western Canada has resulted in a landscape consisting of a mosaic of forest stands at different stages of mortality. Within forest stands, understory communities are...
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Proliferative Signals Regulate Hemocyte Development and Intestinal Immunity in Drosophila melanogaster.
DownloadSpring 2015
The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...
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Spring 2015
Acinetobacter baumannii remains a poorly understood, but very dangerous opportunistic pathogen. Though it lacks clear virulence traits expected of pathogens, it none the less poses a massive threat to the hospital system due to its inherent and acquired resistance to antibiotics, survival on...
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Mathematical modeling and experimental validation of thin low platinum content and functionally graded cathode catalyst layers
DownloadFall 2014
Low catalyst content remains a key requirement for the commercialization of polymer electrolyte fuel cells (PEFCs) into the energy, transportation, and material handling sectors. Understanding the fundamental phenomena reducing fuel cell performance at various stages of operation play a major...
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Mathematical Models and Inverse Algorithms for Childhood Infectious Diseases with Vaccination - Case Studies in Measles
DownloadFall 2014
Children are at a high risk of infection since they have not yet developed mature immunity. Childhood infectious diseases, such as measles, chicken pox and mumps, remain epidemic and endemic around the world. Yet, their dynamics are still not fully understood. SIR-type models have been proposed...
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Fall 2014
In this thesis a mathematical model of HIV transmission and diagnosis is used to estimate the total size of the HIV-positive population and the HIV incidence from HIV case report data for the Province of Alberta. Worldwide, estimates of the size of the HIV-positive population are used to...