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Skip to Search Results- 1Al-Nuaimi, Saleem K
- 1Arvanitidis, Anastasia P
- 1Budd, Alexandra
- 1Chen, Zhong-Xiao.
- 1Connor, Steven
- 1Engin, Elif
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Investigating Human Brain Function and Human Brain Organization Using Functional Magnetic Resonance Imaging at 4.7 T
DownloadFall 2020
Understanding the brain-cognition association has been a major goal of neuroscientists for more than 50 years. The discovery of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) contrast by Ogawa and colleagues (1990, 1992) has fundamentally transformed the field of...
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Spring 2016
Hippocampal activity is characterized by two state-dependent, mutually exclusive large-amplitude oscillations: theta (3-12 Hz) and the hippocampal slow oscillation (SO; ~1 Hz). These two rhythms have been implicated in different stages of memory processing. Theta occurs during awake exploratory...
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Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity
DownloadFall 2010
The acquisition of a behavioural response (learning) and the later retrieval of this response (memory) are separated by an endogenous biological process which consolidates the temporary neural changes initiated by training. Intracerebral infusions of stimulants to the hippocampus potentiate this...
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Fall 2018
Approximately 50 million people worldwide suffer from epilepsy, a chronic neurological disorder characterized by recurrent seizures. While most patients with epilepsy will respond to anticonvulsant medications, approximately one third are found to have drug resistant epilepsy. Mesial temporal...
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Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study
DownloadFall 2012
The hippocampus is a brain structure responsible for memory, learning, and the stress response; it is also used as a model for major depressive disorder (MDD) in preclinical studies. Preclinical models have shown that the hippocampal subfields are differentially affected by chronic stress....
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Fall 2019
Acquisition and storage of episodic-like information fundamentally contributes to quality of life. It is the type of information that allows us to remember meaningful events such as our graduation and our heartaches. The memory of these events allows us to adapt our behaviours to facilitate more...
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NOREPINEPHRINE-MEDIATED SYNAPTIC PLASTICITY: A NOVEL SIGNALING DIALOGUE BETWEEN RECEPTORS AND NUCLEUS
DownloadSpring 2014
Norepinephrine (NE) helps in the consolidation and retention of memories of emotionally charged events. However, the pathway from membrane receptors to nucleus in noradrenergic signaling in the brain is not completely understood. The cyclic AMP-PKA pathway is one of the most studied signaling...
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Fall 2016
Oscillations are a fundamental principle of neural operation, organized into a hierarchy of frequency bands with the dominant rhythm alternating within and across behavioral states. During states of sleep and anesthesia, brain activity in forebrain regions displays two major distinct activity...
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Correlation of Subregional Hippocampal Thickness Abnormalities with Positron Emission Tomography Phosphorylated Tau Measurements in Patients with Mild Cognitive Impairment and Alzheimer's Disease
DownloadFall 2023
Alzheimer’s disease (AD) is the most common cause of dementia and is an emerging public health crisis with 150 million cases projected globally by 2050. Biomarkers are playing an emerging role in AD research - however, existing biomarkers have substantial limitations. Magnetic Resonance Imaging...