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Skip to Search Results- 2Cummine, Jacqueline
- 2Fatama, Kanis
- 2Ngo, Tiffany
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- 1Al-Nuaimi, Saleem K
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- 35Graduate and Postdoctoral Studies (GPS), Faculty of
- 35Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
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- 1St. Stephen's College/Department of Psychotherapy and Spirituality (St. Stephen's College)
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Investigating Human Brain Function and Human Brain Organization Using Functional Magnetic Resonance Imaging at 4.7 T
DownloadFall 2020
Understanding the brain-cognition association has been a major goal of neuroscientists for more than 50 years. The discovery of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) contrast by Ogawa and colleagues (1990, 1992) has fundamentally transformed the field of...
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Spring 2016
Hippocampal activity is characterized by two state-dependent, mutually exclusive large-amplitude oscillations: theta (3-12 Hz) and the hippocampal slow oscillation (SO; ~1 Hz). These two rhythms have been implicated in different stages of memory processing. Theta occurs during awake exploratory...
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Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity
DownloadFall 2010
The acquisition of a behavioural response (learning) and the later retrieval of this response (memory) are separated by an endogenous biological process which consolidates the temporary neural changes initiated by training. Intracerebral infusions of stimulants to the hippocampus potentiate this...
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Fall 2018
Approximately 50 million people worldwide suffer from epilepsy, a chronic neurological disorder characterized by recurrent seizures. While most patients with epilepsy will respond to anticonvulsant medications, approximately one third are found to have drug resistant epilepsy. Mesial temporal...
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Spring 2010
Microglia, the resident immune cells of the central nervous system (CNS), become activated in response to danger signals given out by other cells when homeostasis has been disturbed. Microglial activation is a multifaceted phenomenon that includes numerous distinct phenotypes. The type of...
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Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study
DownloadFall 2012
The hippocampus is a brain structure responsible for memory, learning, and the stress response; it is also used as a model for major depressive disorder (MDD) in preclinical studies. Preclinical models have shown that the hippocampal subfields are differentially affected by chronic stress....
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Fall 2017
This research project is borne out of an invaluable art therapy practicum experience, during which I, the student therapist, encountered a client’s acute emotionality during therapy. As a result, I expanded my academic knowledge, clinical understanding, and sense of professional identity through...
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Fall 2019
Acquisition and storage of episodic-like information fundamentally contributes to quality of life. It is the type of information that allows us to remember meaningful events such as our graduation and our heartaches. The memory of these events allows us to adapt our behaviours to facilitate more...
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NOREPINEPHRINE-MEDIATED SYNAPTIC PLASTICITY: A NOVEL SIGNALING DIALOGUE BETWEEN RECEPTORS AND NUCLEUS
DownloadSpring 2014
Norepinephrine (NE) helps in the consolidation and retention of memories of emotionally charged events. However, the pathway from membrane receptors to nucleus in noradrenergic signaling in the brain is not completely understood. The cyclic AMP-PKA pathway is one of the most studied signaling...