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Skip to Search Results- 2Brian Chwyl
- 2Sandra Campbell
- 1Albo, Susan Karin.
- 1Anderson, Danielle L.
- 1Babadagli, Mustafa E
- 1Baillie, Devin MJ
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Magnetic resonance imaging based radiotherapy treatment planning: problems, solutions, and applications
DownloadFall 2010
Despite their unmatched soft-tissue contrast, Magnetic Resonance (MR) images suffer from wide-ranging image distortions; this has raised questions about their suitability as an imaging modality upon which to base conformal radiation therapy treatment plans. This thesis addresses image distortion...
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Design and simulation of a short, 10 MV, variable energy linear accelerator for use in linac-MR systems
DownloadFall 2016
Hybrid linac-MR devices are currently being designed and constructed by several groups around the world which combine a linear accelerator with an MRI in order to enable real-time 3D imaging to visualize tumor movement during external beam radiotherapy treatments. Each of the current systems is...
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Spring 2012
A promising approach to the development of an integrated system for magnetic resonance imaging-guided radiotherapy involves the rigid coupling of a medical linear accelerator to a rotating biplanar magnet assembly. Through near real-time volumetric imaging during irradiation, this hybrid system...
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Dosimetry and Biological Studies for Microbeam Radiation Therapy at the Canadian Light Source
DownloadFall 2015
Microbeam radiation therapy (MRT) is a pre-clinical type of radiation therapy that uses an array of high-dose microbeams to treat solid tumours. An intense, quasi-parallel synchrotron beam is collimated to create microbeams several 10s of μm wide, and separated by 100s of μm. Animal studies...
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Investigating Radiation in Combination with Oncolytic Vaccinia Virus to Improve the Treatment of Glioblastoma
DownloadFall 2023
Glioblastoma (GBM) is a malignant and immune-suppressed brain cancer that remains incurable despite the current standard of care. Radiotherapy is a mainstay of GBM treatment, however invasive cancer cells outside the irradiated field and radioresistance preclude complete eradication of GBM cells....
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Fall 2010
Real time image guided radiotherapy has been proposed by integrating an in-line 6 MV linear accelerator (linac) to a magnetic resonance (MR) imager in either a parallel or transverse configuration. In either configuration, magnetic interference in the linac is caused by its immersion in the...
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Fall 2016
The integration of clinical linear accelerators (linacs) with magnetic resonance imaging (MRI) systems represent the next generation of image guidance technologies in radiotherapy. Linac-MR systems have several potential advantages over the current X-ray based state-of-the-art image guidance...
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Impact of conventional fractionated RT to pelvic lymph nodes and dose-escalated hypofractionated RT to prostate gland using IMRT treatment delivery in high-risk prostate cancer
DownloadFall 2009
Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve...