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Mammalian orthoreovirus (reovirus) is a non-pathogenic virus that naturally infects through the enteric and respiratory routes. Reoviruses are non-enveloped and have a 10-segment double stranded RNA (dsRNA) genome encased in 2 concentric capsid shells. Representative isolates of each of the 3...
Deletion of F4L (ribonucleotide reductase) in Vaccinia Virus Produces a Selective Oncolytic Virus and Promotes Anti-tumor Immunity with Superior Safety in Bladder CancerDownload
Overall recurrence of non-muscle-invasive bladder cancer (NMIBC) can be as high as 80% within 5 years of initial treatment. High-grade NMIBC has the greatest risk of recurrence and treatment for these patients includes surgery followed by intravesical therapy with the immunotherapeutic agent...
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system. The standard of care for gliomas has remained unchanged for...
Breast cancer (BrCa) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. Current therapies for BrCa are insufficient to cure metastatic disease and are often associated with debilitating side effects that severely deteriorate the quality of patients’...
Investigations into Differences between Vaccinia and Myxoma Virus Plaquing Properties Identifies Strategies for Increasing the Oncolytic Efficacy of Myxoma VirusDownload
Despite both being poxviruses, vaccinia (VACV) and myxoma (MYXV) form very different plaque types. VACV plaques are large and show a central clearing of cells, while MYXV plaques are smaller and result in a clumping of cells. VACV spread is promoted by the formation of an enveloped form of virus...
Hepatocellular carcinoma (HCC) is the fifth most common cancer and third leading cause of cancer-related deaths. Due to the low response to current HCC therapy, many studies have been done to identify novel HCC therapeutics. Non-replicating first generation adenovirus (Ad) vectors and...