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- 4Nucleic acids
- 1All-atom Simulation
- 1Initial excited-state structural dynamics
Initial Excited-State Structural Dynamics and Damage Kinetics of Nucleic Acid Derivatives and a Rhodopsin AnalogueDownload
Photochemical reactions resulting from the absorption of ultraviolet light are one of the main causes of DNA damage. For any excited-state photochemical reaction, it is the structural changes in the excited state after the absorption of the photon that ultimately decide the photochemical fate...
The In-gel polymerase chain reaction (PCR) technology developed by our group at the University of Alberta makes use of PCR reagents entrapped within nano-liter polyacrylamide gels. To adapt this technology for use at the point of care, methods were developed to preserve gel-based PCR reagents by...
Molecular Dynamics Simulations of Polyethylenimine Mediated Nucleic Acid Complexation with Implications for Non-viral Gene DeliveryDownload
Gene therapy is a promising therapeutic technique that involves delivering nucleic acids into cells. Polycations have evolved into a major category of gene carriers. Polyethylenimine (PEI) is one of the most effective polycationic carriers. Furthermore, modifying PEI with certain lipophilic...