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- 5Chan, Catherine B.
- 5Wheeler, Michael B.
- 4Koshkin, Vasilij
- 2Gänzle, Michael G.
- 1Arumugam, Yoga
- 1Asghar, Zeenat
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–)...
Giant vesicles were used to study the rates of uptake of long-chain fatty acids by heart, skeletal muscle, and adipose tissue of obese and lean Zucker rats. With obesity there was an increase in vesicular fatty acid uptake of 1.8-fold in heart, muscle and adipose tissue. In some tissues only...
The insulin receptor (IR) and its signaling appear to be essential for insulin secretion from pancreatic β-cells. However, much less is known about the role of the IR in α-cells. To assess the role of the IR in glucagon and insulin secretion, we engineered adeno-viruses for high efficiency small...
Transport and reaction processes in bioremediation of organic contaminants. 1. Review of bacterial degradation and transportDownload
Bioremediation of contaminants in soil and water involves a complex interplay between transport processes and biological reactions. Equilibrium physical factors such as aqueous solubility, soil adsorption, and phase partitioning indicate the transport processes that can limit bioremediation,...
Excessive free fatty acid (FFA) exposure represents a potentially important diabetogenic condition that can impair insulin secretion from pancreatic β-cells. Because mitochondrial oxidative phosphorylation is a main link between glucose metabolism and insulin secretion, in the present work we...
Effects of aerobic training on the host systemic milieu in patients with solid tumors: An exploratory correlative studyDownload
Stevens, Robert D., Courneya, Kerry S., Inman, Brant A., Muehlbauer, Michael, Nelson, Erik R., Jasper, Jeff, Field, Catherine J., Jones, Lee W., Glass, Oliver K., Bain, James R., Broadwater, Gloria, Goruk, Susan, Hirschey, Matthew D., Mackey, John R.
background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours. patients and methods: Paired peripheral blood...
Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic ß-cellsDownload
Involvement of the mitochondrial permeability transition (MPT) pore in early stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was the focus of this study. Both long term (indirect) and acute (direct) effects of fatty acid (FA) application on β-cell susceptibility to...
Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical rangeDownload
Ruminant livestock are important sources of human food and global greenhouse gas emissions. Feed degradation and methane formation by ruminants rely on metabolic interactions between rumen microbes and affect ruminant productivity. Rumen and camelid foregut microbial community composition was...
Comparative genomics of Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentationsDownload
Lactobacillus reuteri is a dominant member of intestinal microbiota of vertebrates, and occurs in food fermentations. The stable presence of L. reuteri in sourdough provides the opportunity to study the adaptation of vertebrate symbionts to an extra-intestinal habitat. This study evaluated this...
Oligosaccharides, compounds that are composed of 2–10 monosaccharide residues, are major carbohydrate sources in habitats populated by lactobacilli. Moreover, oligosaccharide metabolism is essential for ecological fitness of lactobacilli. Disaccharide metabolism by lactobacilli is well...