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Skip to Search Results- 13Innate immunity
- 4Immunoregulatory receptors
- 3Comparative immunology
- 2Broiler
- 2Canthaxanthin
- 2Internalization
- 1Bartusiak, Robert
- 1Bond, David JE
- 1Cho, Misaki
- 1Choo-Yin, Yemayá Yue
- 1Cortes, Herman D
- 1Fei,Chenjie
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Improving chemotherapeutic regimens by mitigating hearing loss as a limiting side-effect and examining transition metal ions as a ligand for zebrafish Tlr4
DownloadFall 2023
Cancer is often a debilitating disease associated with the uncontrolled growth of cells within an organism. We have made significant strides over the past few decades in treating many cancers, unfortunately, many of these treatments have unfavourable side effects. Cisplatin is a revolutionary...
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Monitoring Macrophage Immune Gene Expression Profiles as an Early Indicator System for Examining the Bioactivity of Oil Sands Process Affected Waters
DownloadFall 2021
Oil sands process-affected waters (OSPW) are by-products of bitumen (i.e. oil) extraction from the oil sands located in northern Alberta. These large volumes of water are held in tailings ponds and cannot be released due to their potential toxic effects. Overall, tailings ponds and mining...
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Identification and Molecular Characterization of Zebrafish (Danio rerio) Leukocyte Immune-Type Receptors (DrLITRs)
DownloadSpring 2020
In response to foreign invaders, innate immune cells use cell surface-expressed receptors to trigger intracellular signalling cascades that control various effector responses designed to destroy microbes. These specialized receptors are known as immunoregulatory receptors and structurally they...
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Examination of channel catfish (Ictalurus punctatus) leukocyte immune-type receptor-mediated crosstalk regulation of phagocytosis
DownloadFall 2020
Across vertebrates, innate immune cells are capable of initiating a range of potent effector responses that are designed to destroy or contain foreign microbial invaders. The execution and regulation of various innate cellular responses is mediated by a dedicated repertoire of cell...
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The effects of broiler breeder diet supplementation of canthaxanthin and 25-hydroxyvitamin D3 and age on offspring performance traits and innate immune function
DownloadSpring 2018
Experiments were conducted to understand the effect of dietary canthaxanthin (CXN) and 25-hydroxyvitamin D3 (25-OHD3) on broiler breeder productivity, progeny performance traits and progeny innate immune function. Beginning at 22 wk of age, breeder hens were fed either 1) Control (Vitamin D3 at...
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Spring 2014
The fine balance struck between life and death is key for the health of all multicellular organisms and therefore the pathways that govern life and death decisions are evolutionarily highly conserved. For example, the human TNF and the Drosophila IMD pathways coordinate signaling elements such...
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Spring 2013
The innate immune system is an evolutionarily conserved first line of defense against invasive microbes. Studies in the fruit fly, Drosophila melanogaster, revolutionized the field of immunology and cemented Drosophila as a premier model of innate immune defenses. The Drosophila immune deficiency...
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Biochemical and Functional Characterization of Inhibitory Leukocyte Immune-Type Receptors in the Channel Catfish (Ictalurus punctatus)
DownloadSpring 2013
Montgomery, Benjamin Christian Sivert
A balance of intracellular signaling events control immune cell functions. In innate immunity, many of these signals are transmitted by subsets of cell surface proteins known as immunoregulatory receptors. Through their recognition of a diverse array of molecules these receptors effectively...
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Fall 2013
In response to pathogens, immune cells induce protective effector functions, such as degranulation, phagocytosis and cytokine secretion, which are initiated by stimulatory or inhibitory immunoregulatory receptors expressed on leukocytes. Using a fish immunological model system, the focus of my...