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Skip to Search Results- 13Innate immunity
- 6Endocytosis
- 4Immunoregulatory receptors
- 3Comparative immunology
- 3Phagocytosis
- 2Broiler
- 1Bartusiak, Robert
- 1Bond, David JE
- 1Cho, Misaki
- 1Choo-Yin, Yemayá Yue
- 1Cortes, Herman D
- 1Fei,Chenjie
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Spring 2013
The innate immune system is an evolutionarily conserved first line of defense against invasive microbes. Studies in the fruit fly, Drosophila melanogaster, revolutionized the field of immunology and cemented Drosophila as a premier model of innate immune defenses. The Drosophila immune deficiency...
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Biochemical and Functional Characterization of Inhibitory Leukocyte Immune-Type Receptors in the Channel Catfish (Ictalurus punctatus)
DownloadSpring 2013
Montgomery, Benjamin Christian Sivert
A balance of intracellular signaling events control immune cell functions. In innate immunity, many of these signals are transmitted by subsets of cell surface proteins known as immunoregulatory receptors. Through their recognition of a diverse array of molecules these receptors effectively...
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Spring 2014
The fine balance struck between life and death is key for the health of all multicellular organisms and therefore the pathways that govern life and death decisions are evolutionarily highly conserved. For example, the human TNF and the Drosophila IMD pathways coordinate signaling elements such...
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Fall 2013
In response to pathogens, immune cells induce protective effector functions, such as degranulation, phagocytosis and cytokine secretion, which are initiated by stimulatory or inhibitory immunoregulatory receptors expressed on leukocytes. Using a fish immunological model system, the focus of my...
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The effect of maternal antioxidant nutrient supplementation and age on chick post-hatch innate immune function
DownloadSpring 2013
The chick’s innate immune system may affect post-hatch liveability and performance, but is immature at hatch. The development of the immune system begins in ovo and may be affected by hen age and nutrition. Antioxidants are molecules capable of preventing and correcting oxidative damage and may...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
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Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...
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The effects of broiler breeder diet supplementation of canthaxanthin and 25-hydroxyvitamin D3 and age on offspring performance traits and innate immune function
DownloadSpring 2018
Experiments were conducted to understand the effect of dietary canthaxanthin (CXN) and 25-hydroxyvitamin D3 (25-OHD3) on broiler breeder productivity, progeny performance traits and progeny innate immune function. Beginning at 22 wk of age, breeder hens were fed either 1) Control (Vitamin D3 at...
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...