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Alternative Requirements for Vestigial, Scalloped, and Dmef2 during Muscle Differentiation in Drosophila melanogaster
Download2009
Bell, J. B., Deng, H., Simmonds, A. J., Hughes, S. C.
Abstract: Vertebrate development requires the activity of the myocyte enhancer factor 2 (mef2) gene family for muscle cell specification and subsequent differentiation. Additionally, several muscle-specific functions of MEF2 family proteins require binding additional cofactors including members...
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The construction and use of bacterial DNA microarrays based on an optimized two-stage PCR strategy
Download2003
Li, H., Klahn, J., Galbraith, D.W., Deyholos, M., Sherman, L.A., Impson, L., Postier, B.L., Risinger, G., Andrews, H.L., Burnap, R.L., Pesta, D., Wang, H.L., Singh, A.
Background: DNA microarrays are a powerful tool with important applications such as global gene expression profiling. Construction of bacterial DNA microarrays from genomic sequence data using a two-stage PCR amplification approach for the production of arrayed DNA is attractive because it...
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Gawky Is a Component of Cytoplasmic mRNA Processing Bodies Required for Early Drosophila Development
Download2006
Hobman, T. C., Locker, J., Schneider, M. D., Pare, J. M., Haskins, J., Simmonds, A. J., Chaker, S., Najand, N
In mammalian cells, the GW182 protein localizes to cytoplasmic bodies implicated in the regulation of messenger RNA ( mRNA) stability, translation, and the RNA interference pathway. Many of these functions have also been assigned to analogous yeast cytoplasmic mRNA processing bodies. We have...
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Spatiotemporal integration of molecular and anatomical data in virtual reality using semantic mapping
Download2009
Janzen, R.P., Dong, X., Gordon, P.M., Soh, J., Wishart, D.S., Sabhaney, A., Turinsky, A.L., Sensen, C.W., Chang, J., Hau, D., Xia, J., Trinh, Q.M.
We have developed a computational framework for spatiotemporal integration of molecular and anatomical datasets in a virtual reality environment. Using two case studies involving gene expression data and pharmacokinetic data, respectively, we demonstrate how existing knowledge bases for molecular...
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Autoregulation of RNA helicase expression in response to temperature stress in Synechocystis spCC 6803
Download2012
Owttrim, George W., Chamot, Danuta, Rosana, Albert R. R.
RNA helicases are ubiquitous enzymes whose modification of RNA secondary structure is known to regulate RNA function. The pathways controlling RNA helicase expression, however, have not been well characterized. Expression of the cyanobacterial RNA helicase, crhR, is regulated in response to...
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2005-09-01
Zhang, Xiuqing , Bolund, Lars , Bao, Jingyue , Ma, Ligeng , Wong, Gane K., Deng, Xing Wang , Wang, Jian , Liu, Xigang , Yuan, Longping , Li, Jian , Zhao, Hongyu , Pedersen, Soren , Wang, Xiangfeng , Wang, Jun , Sun, Ning , Cao, Mengliang , Chen, Chen , Jiao, Yuling , Li, Lin , Su, Ning
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Disentangling detoxification: Gene expression analysis of feeding mountain pine beetle illuminates molecular-level host chemical defense detoxification mechanisms
Download2013-01-01
Bohlmann, Jörg, Bonnett, Tiffany R., Pitt, Caitlin, Keeling, Christopher I., Yuen, Macaire M. S., Huber, Dezene P. W., Robert, Jeanne A.
The mountain pine beetle, Dendroctonus ponderosae, is a native species of bark beetle (Coleoptera: Curculionidae) that caused unprecedented damage to the pine forests of British Columbia and other parts of western North America and is currently expanding its range into the boreal forests of...
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Functional genomics of mountain pine beetle (Dendroctonus ponderosae) midguts and fat bodies
Download2010-01-01
Keeling, Christopher I., Bearfield, Jeremy C., Blomquist, Gary J., Schlauch, Karen, Tittiger, Claus, Young, Sharon, Aw, Tidiane
Background The mountain pine beetle (Dendroctonus ponderosae) is a significant coniferous forest pest in western North America. It relies on aggregation pheromones to colonize hosts. Its three major pheromone components, trans-verbenol, exo-brevicomin, and frontalin, are thought to arise via...
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Generation, annotation, analysis and database integration of 16,500 white spruce EST clusters
Download2005
Johnson, J.E., Pavy, N., Cooke, J., Parsons, L., Paule, C., Morency, M.J., Crow, J.A.
Background: The sequencing and analysis of ESTs is for now the only practical approach for largescale gene discovery and annotation in conifers because their very large genomes are unlikely to be sequenced in the near future. Our objective was to produce extensive collections of ESTs and cDNA...